Downregulation of GABAA receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autism

S H Fatemi, Teri J. Reutiman, Timothy D. Folsom, Oyvind G. Rustan, Robert J. Rooney, Paul D. Thuras

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABAA) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABAA and GABAB subunits and overall reduced protein expression for GABAA receptor alpha 6 (GABRα6), GABAA receptor beta 2 (GABRβ2), GABAA receptor delta (GABRδ), GABA A receptor epsilon (GABRε), GABAA receptor gamma 2 (GABRγ2), GABAA receptor theta (GABRθ), and GABA A receptor rho 2 (GABRρ2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABA A&B subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism.

Original languageEnglish (US)
Pages (from-to)1833-1845
Number of pages13
JournalJournal of Autism and Developmental Disorders
Volume44
Issue number8
DOIs
StatePublished - Jan 1 2014

Keywords

  • Autism
  • Brain
  • Frontal cortex
  • GABA
  • GABRα6
  • GABRβ2

Fingerprint Dive into the research topics of 'Downregulation of GABA<sub>A</sub> receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autism'. Together they form a unique fingerprint.

  • Cite this