Downregulation of CD73 associates with T cell exhaustion in AML patients

Keyphrases

• Acute Myeloid Leukemia 100%
• Leukemia Patients 100%
• T Cell Exhaustion 100%
• CD73 100%
• CD8+ T Cells 20%
• Immune Checkpoint 20%
• T Cells 13%
• Flow Cytometry 13%
• Leukemia 6%
• Adenosine 6%
• Immune Response 6%
• Tumor Cells 6%
• Programmed Death-ligand 1 (PD-L1) 6%
• Antitumor Immune Response 6%
• CD28 6%
• Newly Diagnosed 6%
• Immune Cells 6%
• Cell-to-cell 6%
• Tumor Microenvironment 6%
• Apoptosis 6%
• Blood Samples 6%
• Peripheral Blood 6%
• High-level Expression 6%
• Immune Checkpoint Inhibitors 6%
• Combinational Therapy 6%
• Suppression Effect 6%
• High Susceptibility 6%
• Tumor Tissue 6%
• Stromal Cells 6%
• Functional Status 6%
• Cell Components 6%
• Inhibitory Receptors 6%
• Double-edged Sword 6%
• Cytokine Production 6%
• Target-based Approach 6%
• Ectonucleotidases 6%
• Intracellular Expression 6%
• Phenotypic Study 6%
• Antibody Stimulation 6%
• Eomes 6%
• Cytokine Release Assay 6%
• TIGIT 6%
• Adenosine Signaling 6%
• Successful Treatment 6%
• Anti-tumor Response 6%
• Immune-suppressive 6%
• Anti-leukemia Immunity 6%

Biochemistry, Genetics and Molecular Biology

• Myeloid 100%
• down Regulation 100%
• T Cell 100%
• Immune Checkpoints 50%
• CD8 50%
• Immune Response 33%
• Flow Cytometry 33%
• Adenosine 33%
• Stromal Cell 16%
• Ectonucleotidase 16%
• TIGIT 16%
• Immunocompetent Cell 16%
• Mediator 16%
• CD28 16%
• Cytokine Production 16%
• Functional Status 16%
• Cytokine Release 16%
• Adenosine Monophosphate 16%
• Programmed Cell Death 16%
• Immune Checkpoint Inhibitor 16%

Immunology and Microbiology

• Myeloid 100%
• down Regulation 100%
• T Cell Exhaustion 100%
• Cytotoxic T-Cell 60%
• Immune Response 40%
• T Cell 40%
• Cytokine Release Assays 20%
• CD28 20%
• Immunocompetent Cell 20%
• Mediator 20%
• Tumor Cell 20%
• Cytokine Production 20%
• Cell Component 20%
• Functional Status 20%
• CD3 Antigen 20%
• Programmed Cell Death 20%
• Susceptibility 20%
• In Vitro 20%
• Immune Checkpoint Inhibitor 20%