Down-regulation of guanylate binding protein 1 causes mitochondrial dysfunction and cellular senescence in macrophages

Keyphrases

• Mitochondrial Dysfunction 100%
• Macrophages 100%
• Cellular Senescence 100%
• Guanylate-binding Proteins 100%
• Knockdown 30%
• Metabolic Reprogramming 20%
• Macrophage Polarization 20%
• Aging 10%
• Mitochondrial Function 10%
• Immune Function 10%
• Fatty Acid Oxidation 10%
• Mitophagy 10%
• Adipocyte 10%
• Cellular Aging 10%
• Senescence 10%
• β-Galactosidase (β-Gal) 10%
• Immune Dysfunction 10%
• Aged Mice 10%
• P53 Pathway 10%
• Mitochondrial Fraction 10%
• Electron Transport Chain 10%
• Pro-inflammatory Phenotype 10%
• Chain Component 10%
• Antimicrobial Proteins 10%
• High-fat Diet Mice 10%
• Intracellular Molecules 10%
• Positive Staining 10%
• Mitochondrial Respiratory Function 10%
• Inflammatory Stress 10%
• Inflammatory Macrophages 10%
• Subcutaneous White Adipose Tissue 10%

Biochemistry, Genetics and Molecular Biology

• Macrophage 100%
• Guanylate-Binding Protein 100%
• down Regulation 100%
• Synapsin I 100%
• Mitophagy 10%
• Beta Oxidation 10%
• Cell Aging 10%
• Galactosidase 10%
• Respiratory Function 10%
• Mouse 10%
• Reprogramming 10%
• Electron Transport Chain 10%
• Adipocyte 10%
• P53 10%
• AMP-activated Protein Kinase 10%

Immunology and Microbiology

• Macrophage 100%
• down Regulation 100%
• Protein Binding 100%
• Immune Disorder 10%
• Mouse 10%
• Adipocyte 10%
• Respiratory Chain 10%
• Cell Aging 10%
• Fatty Acid Oxidation 10%
• Respiratory Function 10%
• Inguinal White Adipose Tissue 10%
• P53 10%
• Cytosol 10%
• Mitophagy 10%