Double volume exchange transfusion for ABO incompatible liver transplantation in paediatric patients: Intraoperative and preoperative approach

David S. Beebe, Annie Peña, William Payne, Kumar G. Belani

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Double volume blood exchange transfusions (DBVET) were used to reduce the serum antibody levels in six paediatric patients receiving ABO incompatible hepatic allografts. In four patients, the exchange transfusions took place on the ward prior to surgery. In three of these four patients who had titres measured, the anti-A IgM titres fell from 1024 to 64, 64 to 8, and 128 to 16, respectively. The anti-A IgG titres fell from 32 to 16 and 512 to 64 in two patients, but rose from 16 to 32 in the third. In two patients DBVET were performed intraoperatively using a rapid infusion device. The IgM titres fell from 256 to 32 and 64 to 1, respectively, and the IgG titres fell from 16 to 4 and 2 to 0. Intraoperative DBVET can acutely and effectively reduce blood group antibodies. Intraoperative DBVET may reduce graft ischaemia time and allow red blood cell salvage.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalPaediatric anaesthesia
Volume8
Issue number3
DOIs
StatePublished - Jun 8 1998

Keywords

  • Blood group incompatibility
  • Exchange transfusion
  • Liver transplantation
  • Rapid infusion device

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