Double umbilical cord blood transplantation

Navneet S. Majhail; Claudio G. Brunstein; John E. Wagner

doi:10.1016/j.coi.2006.07.015

Double umbilical cord blood transplantation

Navneet S. Majhail
, Claudio G. Brunstein
, John E. Wagner

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

Unrelated umbilical cord blood (UCB) is an alternative donor source for allogeneic haematopoietic cell transplantation and, compared with unrelated donor bone marrow, has the advantages of rapid availability, greater tolerance of HLA disparity and lower incidence of severe graft-versus-host disease. Graft cell dose is an important determinant of haematopoietic recovery and overall outcome following UCB transplantation, and the limited cell dose of single UCB units has been a major barrier to its more widespread use. Transplantation with two unrelated UCB units is feasible, safe and effective and can overcome the limitation of cell dose of single UCB units.

Original language	English (US)
Pages (from-to)	571-575
Number of pages	5
Journal	Current Opinion in Immunology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.coi.2006.07.015
State	Published - Oct 2006

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10.1016/j.coi.2006.07.015

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@article{d77c6163ce1948c5aa124391d44c2909,

title = "Double umbilical cord blood transplantation",

abstract = "Unrelated umbilical cord blood (UCB) is an alternative donor source for allogeneic haematopoietic cell transplantation and, compared with unrelated donor bone marrow, has the advantages of rapid availability, greater tolerance of HLA disparity and lower incidence of severe graft-versus-host disease. Graft cell dose is an important determinant of haematopoietic recovery and overall outcome following UCB transplantation, and the limited cell dose of single UCB units has been a major barrier to its more widespread use. Transplantation with two unrelated UCB units is feasible, safe and effective and can overcome the limitation of cell dose of single UCB units.",

author = "Majhail, \{Navneet S.\} and Brunstein, \{Claudio G.\} and Wagner, \{John E.\}",

year = "2006",

month = oct,

doi = "10.1016/j.coi.2006.07.015",

language = "English (US)",

volume = "18",

pages = "571--575",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

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TY - JOUR

T1 - Double umbilical cord blood transplantation

AU - Majhail, Navneet S.

AU - Brunstein, Claudio G.

AU - Wagner, John E.

PY - 2006/10

Y1 - 2006/10

N2 - Unrelated umbilical cord blood (UCB) is an alternative donor source for allogeneic haematopoietic cell transplantation and, compared with unrelated donor bone marrow, has the advantages of rapid availability, greater tolerance of HLA disparity and lower incidence of severe graft-versus-host disease. Graft cell dose is an important determinant of haematopoietic recovery and overall outcome following UCB transplantation, and the limited cell dose of single UCB units has been a major barrier to its more widespread use. Transplantation with two unrelated UCB units is feasible, safe and effective and can overcome the limitation of cell dose of single UCB units.

AB - Unrelated umbilical cord blood (UCB) is an alternative donor source for allogeneic haematopoietic cell transplantation and, compared with unrelated donor bone marrow, has the advantages of rapid availability, greater tolerance of HLA disparity and lower incidence of severe graft-versus-host disease. Graft cell dose is an important determinant of haematopoietic recovery and overall outcome following UCB transplantation, and the limited cell dose of single UCB units has been a major barrier to its more widespread use. Transplantation with two unrelated UCB units is feasible, safe and effective and can overcome the limitation of cell dose of single UCB units.

UR - https://www.scopus.com/pages/publications/33748131229

UR - https://www.scopus.com/pages/publications/33748131229#tab=citedBy

U2 - 10.1016/j.coi.2006.07.015

DO - 10.1016/j.coi.2006.07.015

M3 - Review article

C2 - 16895752

AN - SCOPUS:33748131229

SN - 0952-7915

VL - 18

SP - 571

EP - 575

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 5

ER -

Double umbilical cord blood transplantation

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