Double-Edged Metabolic Effects from Short-Term Feeding of Functionalized Wheat Bran to Mouse Revealed by Metabolomic Profiling

Yiwei Ma, Yuwei Lu, Keith Petrofsky, Juer Liu, Yanling Cheng, Roger Ruan, Chi Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Health-promoting activities of wheat bran are limited by the high-degree crosslinking of its dietary fiber and the low bioavailability of its phenolics. In this study, functionalized wheat bran (FWB) was prepared through a combination of milling, alkaline hydrolysis, high-shear mixing, and high-pressure homogenization treatments. Feasibility and metabolic effects of feeding FWB were investigated by a short-term mouse feeding trial and liquid chromatography-mass spectrometry-based metabolomic analysis. The combinatorial processing dramatically enhanced the function-associated physicochemical properties of wheat bran, including viscosity, fiber compositions, free ferulic acid, and antioxidant capacity. FWB feeding led to diverse positive metabolic effects, including fecal sequestration of bile acids and cholesterol, reduced serum triacylglycerols and cholesterol, elevated fermentation for short-chain fatty acids, increased bioavailability of ferulic acid and its microbial metabolites, and improved redox balance. However, FWB feeding also negatively affected the nutritional status by decreasing the bioavailability of essential amino acids through the excessive loss of amino acids in feces and disrupting lipid homeostasis by reducing choline supply in the liver. These double-edged metabolic effects warrant further investigations on how to achieve the balance between the functionalization of wheat bran bioactives and the disruption of nutrient bioavailability.

Original languageEnglish (US)
Pages (from-to)6543-6555
Number of pages13
JournalJournal of agricultural and food chemistry
Volume69
Issue number23
DOIs
StatePublished - Jun 16 2021

Bibliographical note

Funding Information:
This project was supported by the National Research Initiative Grant 2008-01901 from the USDA National Institute of Food and Agriculture (NIFA) and generous gifts from ConAgra Foods (Omaha, Nebraska) and Kellogg’s (Battle Creek, Michigan). Dr. Chi Chen’s research is partially supported by the NIFA project MIN-18-125.

Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.

Keywords

  • dietary fiber
  • ferulic acid
  • functionalization
  • metabolomics
  • wheat bran

PubMed: MeSH publication types

  • Journal Article

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