Double-blind study of lorazepam and diazepam in status epilepticus

Ilo E Leppik, A. T. Derivan, R. W. Homan, J. Walker, R. E. Ramsay, B. Patrick

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Lorazepam was compared with diazepam for the treatment of status epilepticus in a double-blind, randomized trial. Seventy-eight patients with 81 episodes were enrolled. Patients received one or two doses of either 4 mg of lorazepam or 10 mg of diazepam intravenously. Seizures were controlled in 89% of the episodes treated with lorazepam and in 76% treated with diazepam. The times for onset of action of the medications did not differ significantly. Adverse effects occurred in 13% of the lorazepam-treated patients and in 12% of the diazepam-treated patients. Respiratory depression and arrest, the most frequent adverse effects, were treated symptomatically; no adverse sequelae were noted.

Original languageEnglish (US)
Pages (from-to)1452-1454
Number of pages3
JournalJournal of the American Medical Association
Issue number11
StatePublished - May 11 1983


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