Dose-dependent effect of isoflurane on regional cerebral blood flow in anesthetized macaque monkeys

Chun Xia Li, Sudeep Patel, Edward J. Auerbach, Xiaodong Zhang

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53 Scopus citations


The dose-dependent effect of isoflurane on regional CBF of cortical and subcortical structures in anesthetized macaque monkeys was investigated with the Continuous ASL MRI technique. High concentration of isoflurane resulted in global CBF increase and blood pressure decrease. Evident CBF change was observed in the subcortical structures. Specifically, CBF in thalamus and cerebellum was increased about 39% and 55% when isoflurane concentration was changed from 0.75% to 1.5%, respectively. Also, those regional CBF changes correlated linearly with isoflurane inspiratory concentrations, indicating impaired CBF autoregulation in these structures. In contrast, no obvious CBF changes were observed in anterior cingulated cortex, motor cortex, medial prefrontal cortex, and caudate. The results demonstrate that, under the 0.75-1.5% isoflurane maintenance doses, the CBF auto-regulation is well preserved in the cerebral cortical regions and caudate, but impaired in thalamus and cerebellum, indicating disturbed CBF-metabolism coupling and functional response in specific subcortical regions of anesthetized macaque monkeys.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalNeuroscience Letters
StatePublished - Apr 29 2013

Bibliographical note

Funding Information:
The authors are grateful to Wendy Williamson Coyne and Ruth Connelly for animal handling and the anonymous reviewers for their valuable suggestions. The project was funded by the National Center for Research Resources P51RR000165 and is currently supported by the Office of Research Infrastructure Programs/OD P51OD011132 , and by PHS Grant UL1 RR025008 from the Clinical and Translational Science Award program, National Institutes of Health, National Center for Research Resources.


  • Arterial spin labeling (ASL)
  • Auto-regulation
  • Cerebral blood flow (CBF)
  • Dose-dependent effect
  • Isoflurane
  • Non-human primate


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