Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session

Brendan M. Hasz, A. David Redish

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Dorsomedial prefrontal cortex (dmPFC) and hippocampus (HPC) are thought to play complementary roles in a spatial working memory and decision-making network, where spatial information from HPC informs representations in dmPFC, and contextual information from dmPFC biases how HPC recalls that information. We recorded simultaneously from neural ensembles in rodent dmPFC and HPC as rats performed a rule-switching task, and found that ensembles in dmPFC and HPC simultaneously encoded task contingencies and other time-varying information. While ensembles in HPC transitioned to represent new contingencies at the same time as rats updated their strategies to be consistent with the new contingency, dmPFC ensembles transitioned earlier. Neural representations of other time-varying information also changed faster in dmPFC than in HPC. Our results suggest that HPC and dmPFC represent contingencies while simultaneously representing other information which changes over time, and that this contextual information is integrated into hippocampal representations more slowly than in dmPFC.

Original languageEnglish (US)
Article number107215
JournalNeurobiology of Learning and Memory
Volume171
DOIs
StatePublished - May 2020

Bibliographical note

Funding Information:
We thank Christopher Boldt, Kelsey Seeland, and Ayaka Sheehan for technical support and for building the tetrode drives, Christopher Boldt for building the silicon probe drives, Ayaka Sheehan for performing the histology, as well as Onni Rauhala and Daniel Min for help training rats. This work was funded by NSF IGERT Neuroengineering grant DGE-1069104, NIH R01-MH080318, and NIH R01-MH112688.

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • Dorsomedial prefrontal cortex
  • Hippocampus
  • Learning
  • Memory
  • Neuronal representation
  • Prelimbic cortex

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