Dopaminergic therapy disrupts decision-making in impulsive-compulsive Parkinsonian patients

Fabio Taddeini; Erica Ordali; Alessandra Govoni; Francesca Piattellini; Simone Valente; Luca Caremani; Alberto A. Vergani; Ahmet Kaymak; Aldo Rustichini; Eleonora Russo; Chiara Rapallini; Silvia Ramat; Alberto Mazzoni

doi:10.1002/acn3.52249

Dopaminergic therapy disrupts decision-making in impulsive-compulsive Parkinsonian patients

Fabio Taddeini
, Erica Ordali
, Alessandra Govoni
, Francesca Piattellini
, Simone Valente
, Luca Caremani
, Alberto A. Vergani
, Ahmet Kaymak
, Aldo Rustichini
, Eleonora Russo
, Chiara Rapallini
, Silvia Ramat
, Alberto Mazzoni

Economics (Twin Cities)

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB− nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.

Original language	English (US)
Pages (from-to)	631-636
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1002/acn3.52249
State	Published - Mar 2025

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© 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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Taddeini, F., Ordali, E., Govoni, A., Piattellini, F., Valente, S., Caremani, L., Vergani, A. A., Kaymak, A., Rustichini, A., Russo, E., Rapallini, C., Ramat, S., & Mazzoni, A. (2025). Dopaminergic therapy disrupts decision-making in impulsive-compulsive Parkinsonian patients. Annals of Clinical and Translational Neurology, 12(3), 631-636. https://doi.org/10.1002/acn3.52249

Taddeini, F, Ordali, E, Govoni, A, Piattellini, F, Valente, S, Caremani, L, Vergani, AA, Kaymak, A, Rustichini, A, Russo, E, Rapallini, C, Ramat, S & Mazzoni, A 2025, 'Dopaminergic therapy disrupts decision-making in impulsive-compulsive Parkinsonian patients', Annals of Clinical and Translational Neurology, vol. 12, no. 3, pp. 631-636. https://doi.org/10.1002/acn3.52249

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abstract = "Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB− nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.",

author = "Fabio Taddeini and Erica Ordali and Alessandra Govoni and Francesca Piattellini and Simone Valente and Luca Caremani and Vergani, \{Alberto A.\} and Ahmet Kaymak and Aldo Rustichini and Eleonora Russo and Chiara Rapallini and Silvia Ramat and Alberto Mazzoni",

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AU - Taddeini, Fabio

AU - Ordali, Erica

AU - Govoni, Alessandra

AU - Piattellini, Francesca

AU - Valente, Simone

AU - Caremani, Luca

AU - Vergani, Alberto A.

AU - Kaymak, Ahmet

AU - Rustichini, Aldo

AU - Russo, Eleonora

AU - Rapallini, Chiara

AU - Ramat, Silvia

AU - Mazzoni, Alberto

PY - 2025/3

Y1 - 2025/3

N2 - Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB− nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.

AB - Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB− nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.

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JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

IS - 3

ER -

Dopaminergic therapy disrupts decision-making in impulsive-compulsive Parkinsonian patients

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