Dopaminergic modulation of striatal networks in health and Parkinson's disease

D. James Surmeier, Steven M. Graves, Weixing Shen

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


In the last couple of years, there have been significant advances in our understanding of how dopamine modulates striatal circuits underlying goal-directed behaviors and how therapeutic interventions intended to normalize disordered dopaminergic signaling can go awry. This review summarizes some of the advances in this field with a translational focus on Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)109-117
Number of pages9
JournalCurrent opinion in neurobiology
StatePublished - Dec 2014
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from NIH ( NS 34696 and NS 084735 ) and from the IDP and JPB Foundations.


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