Dopaminergic influence on withdrawal jumping behavior in morphine dependent mice

L. F. Tseng, D. A. Brase, H. H. Loh

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Abrupt withdrawal jumping behavior in morphine dependent mice is accompanied by a decrease in brain dopamine turnover and an increase in brain dopamine level which parallel strain differences in jumping incidence. Both naloxone precipitated and abrupt withdrawal jumping behavior are inhibited in a dose dependent manner by the dopamine agonist apomorphine. A cataleptic dose of the dopaminergic antagonist, haloperidol, does not block naloxone precipitated jumping, but does significantly block the inhibition by apomorphine. These findings indicate that there may be a decreased release of dopamine in the brain during the expression of withdrawal jumping behavior and that dopaminergic activation may be inhibitory to this behavior.

Original languageEnglish (US)
Pages (from-to)435-446
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume15
Issue number3
StatePublished - Dec 1 1976

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