Abstract
Abrupt withdrawal jumping behavior in morphine dependent mice is accompanied by a decrease in brain dopamine turnover and an increase in brain dopamine level which parallel strain differences in jumping incidence. Both naloxone precipitated and abrupt withdrawal jumping behavior are inhibited in a dose dependent manner by the dopamine agonist apomorphine. A cataleptic dose of the dopaminergic antagonist, haloperidol, does not block naloxone precipitated jumping, but does significantly block the inhibition by apomorphine. These findings indicate that there may be a decreased release of dopamine in the brain during the expression of withdrawal jumping behavior and that dopaminergic activation may be inhibitory to this behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 435-446 |
| Number of pages | 12 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 15 |
| Issue number | 3 |
| State | Published - 1976 |