We assessed the effects of the dopamine D2 receptor antagonists, sulpiride and raclopride, on conditioned place preference produced by sexual behavior in female Syrian hamsters. Female hamsters treated with sulpiride or raclopride showed high levels of sexual behavior (lordosis) that were equivalent to control females receiving vehicle injections. The degree of place preference conditioning for sulpiride-treated females was marginally reduced, whereas females treated with raclopride showed no evidence of conditioning. These results indicate that conditioned place preference is a useful means for probing the appetitive components of female sexual behavior, and that dopamine D2 receptors are involved in this appetitive process.
Bibliographical noteFunding Information:
We would like to thank Andrew Greendorfer, Adam Hartman, Jason Ribisi, and Brian Schultz for their help with the behavioral testing and conditioning. This research was supported by NSF Grant IBN-9412543 and a grant from the Purdue Research Foundation.
- Conditioned place preference
- Dopamine D receptor