Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice

Yumiko Kaseda, Bernardino Ghetti, Walter C. Low, Judith A. Richter, Jay R. Simon

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Dopamine D2 receptors were studied in homozygous weaver mutant mice (wv/wv), heterozygous littermates (wv/+), and normal mice (+/+). Specific [3H]spiperone binding was significantly higher in the dorsolateral part of the striatum in the weaver mutant mice (wv/wv) than in normal mice (+/+). No significant differences among the3 genotypes were found in other parts of the striatum or in the nucleus accumbens.

Original languageEnglish (US)
Pages (from-to)178-181
Number of pages4
JournalBrain Research
Volume422
Issue number1
DOIs
StatePublished - Sep 29 1987

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • Dopamine
  • Dopamine D receptor binding assay
  • Nucleus accumbens
  • Striatum
  • Supersensitivity
  • Weaver mutant mouse
  • [H]Spiperone

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