Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice

Yumiko Kaseda; Bernardino Ghetti; Walter C. Low; Judith A. Richter; Jay R. Simon

doi:10.1016/0006-8993(87)90555-5

Dopamine D₂ receptors increase in the dorsolateral striatum of weaver mutant mice

Yumiko Kaseda, Bernardino Ghetti, Walter C. Low, Judith A. Richter, Jay R. Simon

Neurosurgery

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Dopamine D₂ receptors were studied in homozygous weaver mutant mice (wv/wv), heterozygous littermates (wv/+), and normal mice (+/+). Specific [³H]spiperone binding was significantly higher in the dorsolateral part of the striatum in the weaver mutant mice (wv/wv) than in normal mice (+/+). No significant differences among the3 genotypes were found in other parts of the striatum or in the nucleus accumbens.

Original language	English (US)
Pages (from-to)	178-181
Number of pages	4
Journal	Brain Research
Volume	422
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90555-5
State	Published - Sep 29 1987

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Dopamine
Dopamine D receptor binding assay
Nucleus accumbens
Striatum
Supersensitivity
Weaver mutant mouse
[H]Spiperone

Publisher link

10.1016/0006-8993(87)90555-5

Find It

Find It at U of M Libraries

Cite this

@article{d41f51c1f3d54e7bb304846f89b979d9,

title = "Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice",

abstract = "Dopamine D2 receptors were studied in homozygous weaver mutant mice (wv/wv), heterozygous littermates (wv/+), and normal mice (+/+). Specific [3H]spiperone binding was significantly higher in the dorsolateral part of the striatum in the weaver mutant mice (wv/wv) than in normal mice (+/+). No significant differences among the3 genotypes were found in other parts of the striatum or in the nucleus accumbens.",

keywords = "Dopamine, Dopamine D receptor binding assay, Nucleus accumbens, Striatum, Supersensitivity, Weaver mutant mouse, [H]Spiperone",

author = "Yumiko Kaseda and Bernardino Ghetti and Low, {Walter C.} and Richter, {Judith A.} and Simon, {Jay R.}",

year = "1987",

month = sep,

day = "29",

doi = "10.1016/0006-8993(87)90555-5",

language = "English (US)",

volume = "422",

pages = "178--181",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Dopamine D2 receptors increase in the dorsolateral striatum of weaver mutant mice

AU - Kaseda, Yumiko

AU - Ghetti, Bernardino

AU - Low, Walter C.

AU - Richter, Judith A.

AU - Simon, Jay R.

PY - 1987/9/29

Y1 - 1987/9/29

N2 - Dopamine D2 receptors were studied in homozygous weaver mutant mice (wv/wv), heterozygous littermates (wv/+), and normal mice (+/+). Specific [3H]spiperone binding was significantly higher in the dorsolateral part of the striatum in the weaver mutant mice (wv/wv) than in normal mice (+/+). No significant differences among the3 genotypes were found in other parts of the striatum or in the nucleus accumbens.

AB - Dopamine D2 receptors were studied in homozygous weaver mutant mice (wv/wv), heterozygous littermates (wv/+), and normal mice (+/+). Specific [3H]spiperone binding was significantly higher in the dorsolateral part of the striatum in the weaver mutant mice (wv/wv) than in normal mice (+/+). No significant differences among the3 genotypes were found in other parts of the striatum or in the nucleus accumbens.

KW - Dopamine

KW - Dopamine D receptor binding assay

KW - Nucleus accumbens

KW - Striatum

KW - Supersensitivity

KW - Weaver mutant mouse

KW - [H]Spiperone

UR - http://www.scopus.com/inward/record.url?scp=0023159013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023159013&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(87)90555-5

DO - 10.1016/0006-8993(87)90555-5

M3 - Article

C2 - 2960423

AN - SCOPUS:0023159013

SN - 0006-8993

VL - 422

SP - 178

EP - 181

JO - Brain Research

JF - Brain Research

IS - 1

ER -