Dopamine agonists induce recovery from surgically-induced septal rage

Rocco F. Marotta, Nancy Logan, Michael Potegal, Murray Glusman, Eliot L. Gardner

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


ALTHOUGH recovery of function following brain damage has long been known to occur, the mechanisms involved are not completely understood1. Of relevance to this problem are reports of pharmacological facilitation of recovery from brain damage in humans2 and from experimentally-induced nervous system lesions in animals3-9. We have previously reported that L-dopa injections produce a dramatic and apparently permanent abolition of the hyper-reactivity or rage syndrome that results from surgical damage to the septal nuclei of the rat forebrain10. Independent confirmation of this finding has also appeared11. We report here that other dopamine agonists share this ability to attenuate or abolish the septal rage syndrome (SRS).

Original languageEnglish (US)
Pages (from-to)513-515
Number of pages3
Issue number5628
StatePublished - 1977


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