TY - JOUR
T1 - Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development
AU - Rana, Vipin S.
AU - Kitsou, Chrysoula
AU - Dutta, Shraboni
AU - Ronzetti, Michael H.
AU - Zhang, Min
AU - Bernard, Quentin
AU - Smith, Alexis A.
AU - Tomás-Cortázar, Julen
AU - Yang, Xiuli
AU - Wu, Ming Jie
AU - Kepple, Oleksandra
AU - Li, Weizhong
AU - Dwyer, Jennifer E.
AU - Matias, Jaqueline
AU - Baljinnyam, Bolormaa
AU - Oliver, Jonathan D.
AU - Rajeevan, Nallakkandi
AU - Pedra, Joao H.F.
AU - Narasimhan, Sukanya
AU - Wang, Yan
AU - Munderloh, Ulrike
AU - Fikrig, Erol
AU - Simeonov, Anton
AU - Anguita, Juan
AU - Pal, Utpal
N1 - Publisher Copyright:
© 2023 American Association for the Advancement of Science. All rights reserved.
PY - 2023/1/13
Y1 - 2023/1/13
N2 - Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-g). Host-derived IFN-g facilitates Dome1-mediated activation of the Ixodes JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting Ixodes vectorial competence. We highlight the evolutionary dependence of I. scapularis on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
AB - Ancestral signaling pathways serve critical roles in metazoan development, physiology, and immunity. We report an evolutionary interspecies communication pathway involving a central Ixodes scapularis tick receptor termed Dome1, which acquired a mammalian cytokine receptor motif exhibiting high affinity for interferon-gamma (IFN-g). Host-derived IFN-g facilitates Dome1-mediated activation of the Ixodes JAK-STAT pathway. This accelerates tick blood meal acquisition and development while upregulating antimicrobial components. The Dome1-JAK-STAT pathway, which exists in most Ixodid tick genomes, regulates the regeneration and proliferation of gut cells-including stem cells-and dictates metamorphosis through the Hedgehog and Notch-Delta networks, ultimately affecting Ixodes vectorial competence. We highlight the evolutionary dependence of I. scapularis on mammalian hosts through cross-species signaling mechanisms that dually influence arthropod immunity and development.
UR - https://www.scopus.com/pages/publications/85146195241
UR - https://www.scopus.com/pages/publications/85146195241#tab=citedBy
U2 - 10.1126/science.abl3837
DO - 10.1126/science.abl3837
M3 - Article
C2 - 36634189
AN - SCOPUS:85146195241
SN - 0036-8075
VL - 379
JO - Science
JF - Science
IS - 6628
M1 - eabl3837
ER -