Does the StarD6 mark the same as the StAR in the nervous system?

In Youb Chang, Young Jin Jeon, Sung Mi Jung, Young Hun Jang, Jong Bae Ahn, Kyung Soo Park, Sang Pil Yoon

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Unlike steroidogenic acute regulatory protein (StAR), one of the cholesterol transport protein, little attention is given to StarD6 which belongs to a family of StAR-related lipid transfer domain proteins. Although we undertook previous works with StarD6 in the nervous system, the characteristics are in controversy to date. Therefore, we attempted to investigate the morphological characteristics of StarD6 in the nervous system are the same as StAR in vitro and in vivo. The number of immunoreactive cells was significantly different by StAR or StarD6 in the cultured glioblastoma cell lines and dopaminergic neuronal cell lines. StarD6 immunoreactivity was changed by the presence of DNA-dependent protein kinase, while the dependency was not observed in StAR immunoreactivity. Besides, StarD6 was mainly observed in the stratum pyramidale and StAR in the other strata of normal rat hippocampus proper. Increased immunolocalization of StAR and StarD6 was seen in the stratum pyramidale and the strata lacunosum-moleculare, respectively, 3. h after pilocarpine-induced epilepsy. Taken together, morphological aspects of StarD6 were significantly different from those of StAR in cultured glial and neuronal cells, as well as the distribution in the normal and epileptic rat hippocampus. These results suggested that StarD6 did not mark the same as StAR in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)239-242
Number of pages4
JournalJournal of Chemical Neuroanatomy
Volume40
Issue number3
DOIs
StatePublished - Nov 2010

Bibliographical note

Funding Information:
This study was supported by research grant by Korea Government, Ministry of Education, Science and Technology ( 2010-0002099 ), and by “ The Institute of Medical Science , Chosun University (2009)”.

Keywords

  • Cultured cells
  • Hippocampus
  • Morphometry
  • START proteins

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