Does Statin Usage Reduce the Risk of Corticosteroid-Related Osteonecrosis in Renal Transplant Population?

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Abstract

The relationship between corticosteroids and osteonecrosis is well known. Limited data suggest that statins modulate cholesterol metabolism and may protect against osteonecrosis. The authors analyzed their prospective renal transplant database to determine if statin usage reduces the incidence of corticosteroid-related osteonecrosis and identified 2,881 renal transplantation patients who met the entry criteria. Among 338 patients on statins, 15 (4.4%) developed osteonecrosis, versus 180 of 2,543 (7%) patients who were not on statins. Osteonecrosis-free survival was similar in patients with and without statin exposure.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalOrthopedic Clinics of North America
Volume40
Issue number2
DOIs
StatePublished - Apr 1 2009

Keywords

  • Avascular necrosis
  • Incidence
  • Osteonecrosis
  • Statins
  • Transplant

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