Does frequency or duration of standing breaks drive changes in glycemic response? A randomized crossover trial

Meynard John L. Toledo; Barbara E. Ainsworth; Glenn A. Gaesser; Steven P. Hooker; Mark A. Pereira; Matthew P. Buman

doi:10.1111/sms.14344

Does frequency or duration of standing breaks drive changes in glycemic response? A randomized crossover trial

Meynard John L. Toledo
, Barbara E. Ainsworth
, Glenn A. Gaesser
, Steven P. Hooker
, Mark A. Pereira
, Matthew P. Buman

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Intervention strategies to break up sitting have mostly focused on the modality (i.e., comparing different intensities and/or type of activities) and less on how frequency and duration of breaks affect health outcomes. This study compared the efficacy of different strategies to break up sitting time [i.e., high frequency, low duration standing breaks (HFLD) and low frequency, high duration standing breaks (LFHD)] in reducing postprandial glucose. Eleven sedentary and prediabetic adults (mean ± SD age = 46.8 ± 10.6 years; 73% female) participated in a cross-over trial. There were six blocks that represented all potential combinations (ordering) of the study conditions and participants were randomly assigned to a block. Each participant underwent three 7.5-h laboratory visits (1 week apart) where they engaged in either continuous sitting, HFLD, or LFHD condition while performing their usual office-related tasks. Standardized breakfast and lunch meals were provided. Postprandial mean glucose, area under the curve (AUC), and incremental area under the curve (iAUC) were evaluated using mixed models. Compared with LFHD condition, the HFLD standing breaks condition significantly lowered mean glucose by −9.94 (−14.13, −5.74) mg/dL·h after lunch, and by −6.23 (−9.93, −2.52) mg/dL·h, for the total lab visit time. Overall, the results favor frequently interrupting sitting with standing breaks to improve glycemic control in individuals with prediabetes. Further studies are needed with larger sample sizes to confirm the results.

Original language	English (US)
Pages (from-to)	1135-1145
Number of pages	11
Journal	Scandinavian Journal of Medicine and Science in Sports
Volume	33
Issue number	7
DOIs	https://doi.org/10.1111/sms.14344
State	Published - Jul 2023

Bibliographical note

Funding Information:
This project was partially supported by the Arizona State University Graduate and Professional Student Association's Graduate Research Support Program, which is funded through ASU's Graduate and Professional Students Association, The Graduate College, and the Office of the Vice Provost for Research. The authors acknowledge the contribution of Dr. Paddy Dempsey for providing a framework for the meal plans used in this study. The authors declare no conflict of interest. All listed authors contributed to the conceptualization of the study design. M.T. collected the study data and drafted the manuscript. All authors reviewed and edited the manuscript.

Funding Information:
This project was partially supported by the Arizona State University Graduate and Professional Student Association's Graduate Research Support Program, which is funded through ASU's Graduate and Professional Students Association, The Graduate College, and the Office of the Vice Provost for Research. The authors acknowledge the contribution of Dr. Paddy Dempsey for providing a framework for the meal plans used in this study. The authors declare no conflict of interest. All listed authors contributed to the conceptualization of the study design. M.T. collected the study data and drafted the manuscript. All authors reviewed and edited the manuscript.

Publisher Copyright:
© 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.

Keywords

continuous glucose monitoring
patterns of breaks
sedentary breaks
sitting interventions
standing breaks

PubMed: MeSH publication types

Randomized Controlled Trial
Journal Article

Publisher link

10.1111/sms.14344

Find It

Find It at U of M Libraries

Cite this

@article{eb2eb69ca7b54e7f88f85e8d9d8e639f,

title = "Does frequency or duration of standing breaks drive changes in glycemic response? A randomized crossover trial",

abstract = "Intervention strategies to break up sitting have mostly focused on the modality (i.e., comparing different intensities and/or type of activities) and less on how frequency and duration of breaks affect health outcomes. This study compared the efficacy of different strategies to break up sitting time [i.e., high frequency, low duration standing breaks (HFLD) and low frequency, high duration standing breaks (LFHD)] in reducing postprandial glucose. Eleven sedentary and prediabetic adults (mean ± SD age = 46.8 ± 10.6 years; 73\% female) participated in a cross-over trial. There were six blocks that represented all potential combinations (ordering) of the study conditions and participants were randomly assigned to a block. Each participant underwent three 7.5-h laboratory visits (1 week apart) where they engaged in either continuous sitting, HFLD, or LFHD condition while performing their usual office-related tasks. Standardized breakfast and lunch meals were provided. Postprandial mean glucose, area under the curve (AUC), and incremental area under the curve (iAUC) were evaluated using mixed models. Compared with LFHD condition, the HFLD standing breaks condition significantly lowered mean glucose by −9.94 (−14.13, −5.74) mg/dL·h after lunch, and by −6.23 (−9.93, −2.52) mg/dL·h, for the total lab visit time. Overall, the results favor frequently interrupting sitting with standing breaks to improve glycemic control in individuals with prediabetes. Further studies are needed with larger sample sizes to confirm the results.",

keywords = "continuous glucose monitoring, patterns of breaks, sedentary breaks, sitting interventions, standing breaks",

author = "Toledo, \{Meynard John L.\} and Ainsworth, \{Barbara E.\} and Gaesser, \{Glenn A.\} and Hooker, \{Steven P.\} and Pereira, \{Mark A.\} and Buman, \{Matthew P.\}",

note = "Funding Information: This project was partially supported by the Arizona State University Graduate and Professional Student Association's Graduate Research Support Program, which is funded through ASU's Graduate and Professional Students Association, The Graduate College, and the Office of the Vice Provost for Research. The authors acknowledge the contribution of Dr. Paddy Dempsey for providing a framework for the meal plans used in this study. The authors declare no conflict of interest. All listed authors contributed to the conceptualization of the study design. M.T. collected the study data and drafted the manuscript. All authors reviewed and edited the manuscript. Funding Information: This project was partially supported by the Arizona State University Graduate and Professional Student Association's Graduate Research Support Program, which is funded through ASU's Graduate and Professional Students Association, The Graduate College, and the Office of the Vice Provost for Research. The authors acknowledge the contribution of Dr. Paddy Dempsey for providing a framework for the meal plans used in this study. The authors declare no conflict of interest. All listed authors contributed to the conceptualization of the study design. M.T. collected the study data and drafted the manuscript. All authors reviewed and edited the manuscript. Publisher Copyright: {\textcopyright} 2023 The Authors. Scandinavian Journal of Medicine \& Science In Sports published by John Wiley \& Sons Ltd.",

year = "2023",

month = jul,

doi = "10.1111/sms.14344",

language = "English (US)",

volume = "33",

pages = "1135--1145",

journal = "Scandinavian Journal of Medicine and Science in Sports",

issn = "0905-7188",

publisher = "Blackwell Munksgaard",

number = "7",

}

TY - JOUR

T1 - Does frequency or duration of standing breaks drive changes in glycemic response? A randomized crossover trial

AU - Toledo, Meynard John L.

AU - Ainsworth, Barbara E.

AU - Gaesser, Glenn A.

AU - Hooker, Steven P.

AU - Pereira, Mark A.

AU - Buman, Matthew P.

N1 - Funding Information: This project was partially supported by the Arizona State University Graduate and Professional Student Association's Graduate Research Support Program, which is funded through ASU's Graduate and Professional Students Association, The Graduate College, and the Office of the Vice Provost for Research. The authors acknowledge the contribution of Dr. Paddy Dempsey for providing a framework for the meal plans used in this study. The authors declare no conflict of interest. All listed authors contributed to the conceptualization of the study design. M.T. collected the study data and drafted the manuscript. All authors reviewed and edited the manuscript. Funding Information: This project was partially supported by the Arizona State University Graduate and Professional Student Association's Graduate Research Support Program, which is funded through ASU's Graduate and Professional Students Association, The Graduate College, and the Office of the Vice Provost for Research. The authors acknowledge the contribution of Dr. Paddy Dempsey for providing a framework for the meal plans used in this study. The authors declare no conflict of interest. All listed authors contributed to the conceptualization of the study design. M.T. collected the study data and drafted the manuscript. All authors reviewed and edited the manuscript. Publisher Copyright: © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.

PY - 2023/7

Y1 - 2023/7

N2 - Intervention strategies to break up sitting have mostly focused on the modality (i.e., comparing different intensities and/or type of activities) and less on how frequency and duration of breaks affect health outcomes. This study compared the efficacy of different strategies to break up sitting time [i.e., high frequency, low duration standing breaks (HFLD) and low frequency, high duration standing breaks (LFHD)] in reducing postprandial glucose. Eleven sedentary and prediabetic adults (mean ± SD age = 46.8 ± 10.6 years; 73% female) participated in a cross-over trial. There were six blocks that represented all potential combinations (ordering) of the study conditions and participants were randomly assigned to a block. Each participant underwent three 7.5-h laboratory visits (1 week apart) where they engaged in either continuous sitting, HFLD, or LFHD condition while performing their usual office-related tasks. Standardized breakfast and lunch meals were provided. Postprandial mean glucose, area under the curve (AUC), and incremental area under the curve (iAUC) were evaluated using mixed models. Compared with LFHD condition, the HFLD standing breaks condition significantly lowered mean glucose by −9.94 (−14.13, −5.74) mg/dL·h after lunch, and by −6.23 (−9.93, −2.52) mg/dL·h, for the total lab visit time. Overall, the results favor frequently interrupting sitting with standing breaks to improve glycemic control in individuals with prediabetes. Further studies are needed with larger sample sizes to confirm the results.

AB - Intervention strategies to break up sitting have mostly focused on the modality (i.e., comparing different intensities and/or type of activities) and less on how frequency and duration of breaks affect health outcomes. This study compared the efficacy of different strategies to break up sitting time [i.e., high frequency, low duration standing breaks (HFLD) and low frequency, high duration standing breaks (LFHD)] in reducing postprandial glucose. Eleven sedentary and prediabetic adults (mean ± SD age = 46.8 ± 10.6 years; 73% female) participated in a cross-over trial. There were six blocks that represented all potential combinations (ordering) of the study conditions and participants were randomly assigned to a block. Each participant underwent three 7.5-h laboratory visits (1 week apart) where they engaged in either continuous sitting, HFLD, or LFHD condition while performing their usual office-related tasks. Standardized breakfast and lunch meals were provided. Postprandial mean glucose, area under the curve (AUC), and incremental area under the curve (iAUC) were evaluated using mixed models. Compared with LFHD condition, the HFLD standing breaks condition significantly lowered mean glucose by −9.94 (−14.13, −5.74) mg/dL·h after lunch, and by −6.23 (−9.93, −2.52) mg/dL·h, for the total lab visit time. Overall, the results favor frequently interrupting sitting with standing breaks to improve glycemic control in individuals with prediabetes. Further studies are needed with larger sample sizes to confirm the results.

KW - continuous glucose monitoring

KW - patterns of breaks

KW - sedentary breaks

KW - sitting interventions

KW - standing breaks

UR - https://www.scopus.com/pages/publications/85150342768

UR - https://www.scopus.com/pages/publications/85150342768#tab=citedBy

U2 - 10.1111/sms.14344

DO - 10.1111/sms.14344

M3 - Article

C2 - 36840389

AN - SCOPUS:85150342768

SN - 0905-7188

VL - 33

SP - 1135

EP - 1145

JO - Scandinavian Journal of Medicine and Science in Sports

JF - Scandinavian Journal of Medicine and Science in Sports

IS - 7

ER -

Does frequency or duration of standing breaks drive changes in glycemic response? A randomized crossover trial

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Publisher link

Find It

Other files and links

Fingerprint

Cite this