Does electrospray ionization produce gas-phase or liquid-phase structures?

Zhixin Tian, Steven R. Kass

Research output: Contribution to journalArticlepeer-review

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Electrospray ionization of tyrosine from a 3:1 (v:v) CH3OH/H2O solution is found to afford an M - H ion which is a 70:30 mixture of phenoxide and carboxylate ions. This corresponds to the gas-phase equilibrium composition and not the liquid-phase proportions. In contrast, the carboxylate is produced as the dominant ion (∼95%) from anhydrous CH3CN and CH3CN/H2O mixtures. The addition of small amounts of CH3OH to the solvent, however, convert the M - H ion back into the gas-phase isomeric ratio. The isomeric structure therefore depends on the solvent system from which an ion is sprayed.

Original languageEnglish (US)
Pages (from-to)10842-10843
Number of pages2
JournalJournal of the American Chemical Society
Issue number33
StatePublished - Aug 20 2008


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