Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence

Rachel Wong; Emily Lam; Carolyn T. Bramante; Steven G. Johnson; Jane Reusch; Kenneth J. Wilkins; Hsin Chieh Yeh

doi:10.1007/s11892-023-01515-1

Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence

Rachel Wong, Emily Lam, Carolyn T. Bramante, Steven G. Johnson, Jane Reusch, Kenneth J. Wilkins, Hsin Chieh Yeh

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Purpose of Review: Multiple studies report an increased incidence of diabetes following SARS-CoV-2 infection. Given the potential increased global burden of diabetes, understanding the effect of SARS-CoV-2 in the epidemiology of diabetes is important. Our aim was to review the evidence pertaining to the risk of incident diabetes after COVID-19 infection. Recent Findings: Incident diabetes risk increased by approximately 60% compared to patients without SARS-CoV-2 infection. Risk also increased compared to non-COVID-19 respiratory infections, suggesting SARS-CoV-2-mediated mechanisms rather than general morbidity after respiratory illness. Evidence is mixed regarding the association between SARS-CoV-2 infection and T1D. SARS-CoV-2 infection is associated with an elevated risk of T2D, but it is unclear whether the incident diabetes is persistent over time or differs in severity over time. Summary: SARS-CoV-2 infection is associated with an increased risk of incident diabetes. Future studies should evaluate vaccination, viral variant, and patient- and treatment-related factors that influence risk.

Original language	English (US)
Pages (from-to)	207-216
Number of pages	10
Journal	Current diabetes reports
Volume	23
Issue number	8
DOIs	https://doi.org/10.1007/s11892-023-01515-1
State	Published - Aug 2023

Bibliographical note

Funding Information:
Dr. Wong receives grant support from the National Institutes of Health Agreement OTA OT2HL161847 as part of the Researching COVID to Enhance Recovery (RECOVER) research program. Dr. Bramante is funded by the National Institute of Digestive, Diabetes, and Kidney Diseases K23DK124654; and Drs. Wong, Reusch, Johnson, Yeh by 3R01DK130351-02S1, National Institutes of Health (NIH). All other authors declare no competing interests.

Publisher Copyright:
© 2023, The Author(s).

Keywords

COVID-19
Incident diabetes
SARS-CoV-2
Type 1 diabetes
Type 2 diabetes

PubMed: MeSH publication types

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11892-023-01515-1

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abstract = "Purpose of Review: Multiple studies report an increased incidence of diabetes following SARS-CoV-2 infection. Given the potential increased global burden of diabetes, understanding the effect of SARS-CoV-2 in the epidemiology of diabetes is important. Our aim was to review the evidence pertaining to the risk of incident diabetes after COVID-19 infection. Recent Findings: Incident diabetes risk increased by approximately 60% compared to patients without SARS-CoV-2 infection. Risk also increased compared to non-COVID-19 respiratory infections, suggesting SARS-CoV-2-mediated mechanisms rather than general morbidity after respiratory illness. Evidence is mixed regarding the association between SARS-CoV-2 infection and T1D. SARS-CoV-2 infection is associated with an elevated risk of T2D, but it is unclear whether the incident diabetes is persistent over time or differs in severity over time. Summary: SARS-CoV-2 infection is associated with an increased risk of incident diabetes. Future studies should evaluate vaccination, viral variant, and patient- and treatment-related factors that influence risk.",

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author = "Rachel Wong and Emily Lam and Bramante, {Carolyn T.} and Johnson, {Steven G.} and Jane Reusch and Wilkins, {Kenneth J.} and Yeh, {Hsin Chieh}",

note = "Funding Information: Dr. Wong receives grant support from the National Institutes of Health Agreement OTA OT2HL161847 as part of the Researching COVID to Enhance Recovery (RECOVER) research program. Dr. Bramante is funded by the National Institute of Digestive, Diabetes, and Kidney Diseases K23DK124654; and Drs. Wong, Reusch, Johnson, Yeh by 3R01DK130351-02S1, National Institutes of Health (NIH). All other authors declare no competing interests. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

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AU - Lam, Emily

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AU - Johnson, Steven G.

AU - Reusch, Jane

AU - Wilkins, Kenneth J.

AU - Yeh, Hsin Chieh

N1 - Funding Information: Dr. Wong receives grant support from the National Institutes of Health Agreement OTA OT2HL161847 as part of the Researching COVID to Enhance Recovery (RECOVER) research program. Dr. Bramante is funded by the National Institute of Digestive, Diabetes, and Kidney Diseases K23DK124654; and Drs. Wong, Reusch, Johnson, Yeh by 3R01DK130351-02S1, National Institutes of Health (NIH). All other authors declare no competing interests. Publisher Copyright: © 2023, The Author(s).

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N2 - Purpose of Review: Multiple studies report an increased incidence of diabetes following SARS-CoV-2 infection. Given the potential increased global burden of diabetes, understanding the effect of SARS-CoV-2 in the epidemiology of diabetes is important. Our aim was to review the evidence pertaining to the risk of incident diabetes after COVID-19 infection. Recent Findings: Incident diabetes risk increased by approximately 60% compared to patients without SARS-CoV-2 infection. Risk also increased compared to non-COVID-19 respiratory infections, suggesting SARS-CoV-2-mediated mechanisms rather than general morbidity after respiratory illness. Evidence is mixed regarding the association between SARS-CoV-2 infection and T1D. SARS-CoV-2 infection is associated with an elevated risk of T2D, but it is unclear whether the incident diabetes is persistent over time or differs in severity over time. Summary: SARS-CoV-2 infection is associated with an increased risk of incident diabetes. Future studies should evaluate vaccination, viral variant, and patient- and treatment-related factors that influence risk.

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KW - Incident diabetes

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KW - Type 1 diabetes

KW - Type 2 diabetes

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Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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