Does autoimmune pancreatitis increase the risk of pancreatic carcinoma? A retrospective analysis of pancreatic resections

Rajib Gupta, Arezou Khosroshahi, Shweta Shinagare, Carlos Fernandez, Cristina Ferrone, Gregory Y. Lauwers, John H. Stone, Vikram Deshpande

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and 30 cases of chronic pancreatitis not otherwise specified (CP-NOS). We also reviewed a cohort of 84 AIP cases. RESULTS: The mean age of the AIP cohort (57 years) was significantly higher than that of the cohort of CP-NOS (47 years) (P = 0.01). Twenty-three cases (82%) of AIP showed PanIN, and 7 cases (25%) showed grade 2 PanIN. Grade 3 PanIN was identified in one case of AIP. There was no statistically significant difference in the number of cases with high-grade PanIN lesions between the cases of type 1 as opposed to type 2 AIP. In comparison to CP-NOS, a comparable percentage of patients with AIP had PanIN (82% of AIP cases vs 63% of CP-NOS cases) (P = NS) and PanIN 2 (25% AIP vs 20% CP-NOS) (P = NS). Of the 84 AIP cases at our institution (mean follow-up, 49 months), 2 cases of pancreatic carcinoma were identified 6 and 10 years after the diagnoses of AIP. CONCLUSIONS: These findings raise concern that AIP is associated with an elevated risk of malignancy and should prompt additional studies.

Original languageEnglish (US)
Pages (from-to)506-510
Number of pages5
JournalPancreas
Volume42
Issue number3
DOIs
StatePublished - Apr 1 2013

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Pancreatitis
Chronic Pancreatitis
Neoplasms
Pancreatic Carcinoma
Pancreas

Keywords

  • Autoimmune pancreatitis
  • Chronic pancreatitis
  • IgG4-related disease
  • Pancreatic carcinoma

Cite this

Gupta, R., Khosroshahi, A., Shinagare, S., Fernandez, C., Ferrone, C., Lauwers, G. Y., ... Deshpande, V. (2013). Does autoimmune pancreatitis increase the risk of pancreatic carcinoma? A retrospective analysis of pancreatic resections. Pancreas, 42(3), 506-510. https://doi.org/10.1097/MPA.0b013e31826bef91

Does autoimmune pancreatitis increase the risk of pancreatic carcinoma? A retrospective analysis of pancreatic resections. / Gupta, Rajib; Khosroshahi, Arezou; Shinagare, Shweta; Fernandez, Carlos; Ferrone, Cristina; Lauwers, Gregory Y.; Stone, John H.; Deshpande, Vikram.

In: Pancreas, Vol. 42, No. 3, 01.04.2013, p. 506-510.

Research output: Contribution to journalArticle

Gupta, R, Khosroshahi, A, Shinagare, S, Fernandez, C, Ferrone, C, Lauwers, GY, Stone, JH & Deshpande, V 2013, 'Does autoimmune pancreatitis increase the risk of pancreatic carcinoma? A retrospective analysis of pancreatic resections', Pancreas, vol. 42, no. 3, pp. 506-510. https://doi.org/10.1097/MPA.0b013e31826bef91
Gupta, Rajib ; Khosroshahi, Arezou ; Shinagare, Shweta ; Fernandez, Carlos ; Ferrone, Cristina ; Lauwers, Gregory Y. ; Stone, John H. ; Deshpande, Vikram. / Does autoimmune pancreatitis increase the risk of pancreatic carcinoma? A retrospective analysis of pancreatic resections. In: Pancreas. 2013 ; Vol. 42, No. 3. pp. 506-510.
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AB - OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and 30 cases of chronic pancreatitis not otherwise specified (CP-NOS). We also reviewed a cohort of 84 AIP cases. RESULTS: The mean age of the AIP cohort (57 years) was significantly higher than that of the cohort of CP-NOS (47 years) (P = 0.01). Twenty-three cases (82%) of AIP showed PanIN, and 7 cases (25%) showed grade 2 PanIN. Grade 3 PanIN was identified in one case of AIP. There was no statistically significant difference in the number of cases with high-grade PanIN lesions between the cases of type 1 as opposed to type 2 AIP. In comparison to CP-NOS, a comparable percentage of patients with AIP had PanIN (82% of AIP cases vs 63% of CP-NOS cases) (P = NS) and PanIN 2 (25% AIP vs 20% CP-NOS) (P = NS). Of the 84 AIP cases at our institution (mean follow-up, 49 months), 2 cases of pancreatic carcinoma were identified 6 and 10 years after the diagnoses of AIP. CONCLUSIONS: These findings raise concern that AIP is associated with an elevated risk of malignancy and should prompt additional studies.

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