Abstract
OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and 30 cases of chronic pancreatitis not otherwise specified (CP-NOS). We also reviewed a cohort of 84 AIP cases. RESULTS: The mean age of the AIP cohort (57 years) was significantly higher than that of the cohort of CP-NOS (47 years) (P = 0.01). Twenty-three cases (82%) of AIP showed PanIN, and 7 cases (25%) showed grade 2 PanIN. Grade 3 PanIN was identified in one case of AIP. There was no statistically significant difference in the number of cases with high-grade PanIN lesions between the cases of type 1 as opposed to type 2 AIP. In comparison to CP-NOS, a comparable percentage of patients with AIP had PanIN (82% of AIP cases vs 63% of CP-NOS cases) (P = NS) and PanIN 2 (25% AIP vs 20% CP-NOS) (P = NS). Of the 84 AIP cases at our institution (mean follow-up, 49 months), 2 cases of pancreatic carcinoma were identified 6 and 10 years after the diagnoses of AIP. CONCLUSIONS: These findings raise concern that AIP is associated with an elevated risk of malignancy and should prompt additional studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 506-510 |
| Number of pages | 5 |
| Journal | Pancreas |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1 2013 |
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Keywords
- Autoimmune pancreatitis
- Chronic pancreatitis
- IgG4-related disease
- Pancreatic carcinoma
Cite this
Does autoimmune pancreatitis increase the risk of pancreatic carcinoma? A retrospective analysis of pancreatic resections. / Gupta, Rajib; Khosroshahi, Arezou; Shinagare, Shweta; Fernandez, Carlos; Ferrone, Cristina; Lauwers, Gregory Y.; Stone, John H.; Deshpande, Vikram.
In: Pancreas, Vol. 42, No. 3, 01.04.2013, p. 506-510.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does autoimmune pancreatitis increase the risk of pancreatic carcinoma?
T2 - A retrospective analysis of pancreatic resections
AU - Gupta, Rajib
AU - Khosroshahi, Arezou
AU - Shinagare, Shweta
AU - Fernandez, Carlos
AU - Ferrone, Cristina
AU - Lauwers, Gregory Y.
AU - Stone, John H.
AU - Deshpande, Vikram
PY - 2013/4/1
Y1 - 2013/4/1
N2 - OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and 30 cases of chronic pancreatitis not otherwise specified (CP-NOS). We also reviewed a cohort of 84 AIP cases. RESULTS: The mean age of the AIP cohort (57 years) was significantly higher than that of the cohort of CP-NOS (47 years) (P = 0.01). Twenty-three cases (82%) of AIP showed PanIN, and 7 cases (25%) showed grade 2 PanIN. Grade 3 PanIN was identified in one case of AIP. There was no statistically significant difference in the number of cases with high-grade PanIN lesions between the cases of type 1 as opposed to type 2 AIP. In comparison to CP-NOS, a comparable percentage of patients with AIP had PanIN (82% of AIP cases vs 63% of CP-NOS cases) (P = NS) and PanIN 2 (25% AIP vs 20% CP-NOS) (P = NS). Of the 84 AIP cases at our institution (mean follow-up, 49 months), 2 cases of pancreatic carcinoma were identified 6 and 10 years after the diagnoses of AIP. CONCLUSIONS: These findings raise concern that AIP is associated with an elevated risk of malignancy and should prompt additional studies.
AB - OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and 30 cases of chronic pancreatitis not otherwise specified (CP-NOS). We also reviewed a cohort of 84 AIP cases. RESULTS: The mean age of the AIP cohort (57 years) was significantly higher than that of the cohort of CP-NOS (47 years) (P = 0.01). Twenty-three cases (82%) of AIP showed PanIN, and 7 cases (25%) showed grade 2 PanIN. Grade 3 PanIN was identified in one case of AIP. There was no statistically significant difference in the number of cases with high-grade PanIN lesions between the cases of type 1 as opposed to type 2 AIP. In comparison to CP-NOS, a comparable percentage of patients with AIP had PanIN (82% of AIP cases vs 63% of CP-NOS cases) (P = NS) and PanIN 2 (25% AIP vs 20% CP-NOS) (P = NS). Of the 84 AIP cases at our institution (mean follow-up, 49 months), 2 cases of pancreatic carcinoma were identified 6 and 10 years after the diagnoses of AIP. CONCLUSIONS: These findings raise concern that AIP is associated with an elevated risk of malignancy and should prompt additional studies.
KW - Autoimmune pancreatitis
KW - Chronic pancreatitis
KW - IgG4-related disease
KW - Pancreatic carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84884211652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884211652&partnerID=8YFLogxK
U2 - 10.1097/MPA.0b013e31826bef91
DO - 10.1097/MPA.0b013e31826bef91
M3 - Article
C2 - 23271394
AN - SCOPUS:84884211652
VL - 42
SP - 506
EP - 510
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 3
ER -