Do sleep disturbances contribute to comorbidities in HIV?

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Purpose of reviewTo highlight recent publications about sleep disorders and sleep health in adult persons with HIV (PWH), with a focus on how sleep relates to comorbidities in PWH.Recent findingsSleep disorders are more common in PWH than in seronegative controls, especially insomnia, with four different recent studies estimating insomnia prevalence in PWH at 21-35%. Sleep apnea prevalence estimates in PWH have varied widely. Most studies suggest PWH do not have higher sleep apnea prevalence compared with controls, though definitions of sleep apnea may affect these analyses. Comorbidities recently associated with sleep in PWH include myocardial infraction (insomnia), depressive symptoms (insomnia and restless legs syndrome), and pain (insomnia). Cognition associations with sleep were inconsistent and may depend on data collection and analytic methods. Sleep health dimensions are uncommonly reported, but PWH appear to report worse sleep health dimensions and these demonstrated mixed associations with cognition and depressive symptoms in recent studies.SummarySleep disorders and poor sleep health are common in PWH and are related to comorbidities. More data from longitudinal studies and clinical trials are needed. Clinical trials of insomnia interventions in PWH are especially warranted.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalCurrent Opinion in HIV and AIDS
Issue number2
StatePublished - Mar 1 2023

Bibliographical note

Funding Information:
This material is the result of work supported with resources and the use of facilities at the Minneapolis Veterans Affairs Medical Center, Minneapolis, USA. This work was also supported by grant support K.M.K. received for HIV-associated comorbidity research from the National Institutes of Health (U01 HL146208, U01 HL146193).

Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.


  • anxiety
  • cardiovascular disease
  • depression
  • HIV
  • insomnia
  • neuropsychological tests
  • obstructive sleep apnea
  • pain
  • restless legs syndrome
  • sleep

PubMed: MeSH publication types

  • Review
  • Journal Article
  • Research Support, N.I.H., Extramural


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