Do memory B cells form secondary germinal centers? It depends

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The memory B-cell pool in an immune individual is more heterogeneous than previously recognized. The different types of memory B cells likely play distinct roles in tuning the secondary immune response because they differ in their potential to generate plasmablasts, which secrete antibodies, or germinal center (GC) cells, which generate new and higher affinity memory cells. We propose that the production of plasmablasts or GC cells by a memory B cell is controlled by its state of differentiation and the amount and affinity of antigen-specific antibodies present in the individual in which it resides.

Original languageEnglish (US)
Article numbera029116
JournalCold Spring Harbor Perspectives in Biology
Issue number1
StatePublished - Jan 2018

Bibliographical note

Publisher Copyright:
© 2018 Cold Spring Harbor Laboratory Press; all rights reserved.


Dive into the research topics of 'Do memory B cells form secondary germinal centers? It depends'. Together they form a unique fingerprint.

Cite this