Do longevity mutants always show trade-offs?

Wayne A. Van Voorhies, James W. Curtsinger, Michael R. Rose

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


A number of genetic mutations that substantially increase longevity have been discovered in model organisms. Although these long-lived mutants have provided many insights into the factors that affect longevity, the results from such studies should be interpreted with caution. In particular, at least some of these mutations may be poor guides to human medical intervention because they often have deleterious side effects on important biological functions.

Original languageEnglish (US)
Pages (from-to)1055-1058
Number of pages4
JournalExperimental Gerontology
Issue number10
StatePublished - Oct 2006


  • Aging
  • Caenorhabditis elegans
  • Drosophila melanogaster
  • Mus musculus


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