Do corticosteroids play a role in the management of traumatic brain injury?

Reid Hoshide, Vincent Cheung, Lawrence Marshall, Ekkehard Kasper, Clark C. Chen

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Neuroprotective strategies for the medical management of traumatic brain injury (TBI) have been elusive. While laboratory studies provide a conceptual framework for the potential efficacy of corticosteroids in this context, clinical trials testing this hypothesis have yielded no convincing evidence of clinical benefit. Here, we review the five key randomized control trials (RCTs) that have examined this issue. Based on the proposed primary endpoints of these RCTs, the five RCTs consistently showed that corticosteroids do not confer significant benefit in the TBI population. Copy; 2016 Surgical Neurology International | Published by Wolters Kluwer - Medknow.

Original languageEnglish (US)
Article number84
JournalSurgical Neurology International
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Outcomes
  • TBI
  • randomized controlled trials
  • steroids
  • traumatic brain injury

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