Do consumers avoid viewing over-the-counter (OTC) pharmaceutical advertisements? And, if so, why? The authors of the current study tested their proposed Ad Avoidance Model by surveying a nationally-representative sample of U.S. adults about their reactions to advertisements for OTC drugs (specifically analgesics). The researchers focused on how four advertising-reaction factors—two cognitive (perceived utility and skepticism) and two affective (irritation and attitude toward advertising)—influenced avoidance behaviors. The results revealed that avoidance was directly linked to irritation and attitude, although attitude also partially mediated the relationship between irritation and avoidance. Age and socioeconomic status also played roles in these relationships.