DNA unhooking from a single post as a deterministic process: Insights from translocation modeling

Nabil Laachi, Jaeseol Cho, Kevin D. Dorfman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Using stochastic methods developed for DNA translocation through nanopores, we study the unhooking of a long DNA chain from an isolated stationary micropost. Such methods quickly and efficiently furnish both the full probability distribution of the unhooking time and the ensuing moments for a wide range of chain and field parameters. The results compare favorably to more realistic but computationally intense Brownian dynamics simulations. For typical chain lengths and applied electric fields used in experiments, the unhooking process is effectively deterministic; diffusive fluctuations make a negligible contribution to the first and second moments of the unhooking time. This result lends credence to continuous-time random-walk models of the overall transport process that treat the unhooking as a convective process.

Original languageEnglish (US)
Article number031928
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume79
Issue number3
DOIs
StatePublished - Mar 3 2009

Fingerprint Dive into the research topics of 'DNA unhooking from a single post as a deterministic process: Insights from translocation modeling'. Together they form a unique fingerprint.

  • Cite this