The study of DNA replication in eukaryotic chromosomes has revealed a multitude of different regulatory levels. Nuclear and chromosomal location as well as chromatin structure may affect the activity of replication origins and their modulation during development.
Bibliographical noteFunding Information:
AK Bielinsky was supported by the Krause Family Special fellowship of the Leukemia and Lymphoma Society. We thank the National Institutes of Health for its support of our research on replication (grant GM35929 to SA Gerbi).