DNA repair variants, indoor tanning, and risk of melanoma

Salina M. Torres, Li Luo, Jenna Lilyquist, Christine A. Stidley, Kristina Flores, Kirsten A.M. White, Esther Erdei, Melissa Gonzales, Susan Paine, Rachel I. Vogel, Deann Lazovich, Marianne Berwick

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Summary: Although ultraviolet radiation (UV) exposure from indoor tanning has been linked to an increased risk of melanoma, the role of DNA repair genes in this process is unknown. We evaluated the association of 92 single nucleotide polymorphisms (SNPs) in 20 DNA repair genes with the risk of melanoma and indoor tanning among 929 patients with melanoma and 817 controls from the Minnesota Skin Health Study. Significant associations with melanoma risk were identified for SNPs in ERCC4, ERCC6, RFC1, XPC, MGMT, and FBRSL1 genes; with a cutoff of P < 0.05. ERCC6 and FBRSL1 gene variants and haplotypes interacted with indoor tanning. However, none of the 92 SNPs tested met the correction criteria for multiple comparisons. This study, based on an a priori interest in investigating the role of DNA repair capacity using variants in base excision and nucleotide excision repair, identified several genes that may play a role in resolving UV-induced DNA damage.

Original languageEnglish (US)
Pages (from-to)677-684
Number of pages8
JournalPigment Cell and Melanoma Research
Volume26
Issue number5
DOIs
StatePublished - Sep 2013

Keywords

  • Artificial UV
  • DNA repair
  • Gene-environment interaction
  • Indoor tanning
  • Melanoma
  • Single nucleotide polymorphisms

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