DNA ligase and PCNA: Double-ring down to seal a break in DNA

Hideki Aihara

doi:10.1016/j.str.2022.02.008

DNA ligase and PCNA: Double-ring down to seal a break in DNA

Hideki Aihara

Chemical and Structural Biology (BMBB)

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.

Original language	English (US)
Pages (from-to)	324-326
Number of pages	3
Journal	Structure
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.str.2022.02.008
State	Published - Mar 3 2022

Bibliographical note

Funding Information:
The author thanks Nicholas Moeller for helpful comments. H.A. is supported by NIGMS R35-GM118047 .

Publisher Copyright:
© 2022 Elsevier Ltd

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
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10.1016/j.str.2022.02.008

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abstract = "In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.",

author = "Hideki Aihara",

note = "Funding Information: The author thanks Nicholas Moeller for helpful comments. H.A. is supported by NIGMS R35-GM118047 . Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

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DNA ligase and PCNA: Double-ring down to seal a break in DNA

Abstract

Bibliographical note

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