In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.
Bibliographical noteFunding Information:
The author thanks Nicholas Moeller for helpful comments. H.A. is supported by NIGMS R35-GM118047 .
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