Abstract
In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.
Original language | English (US) |
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Pages (from-to) | 324-326 |
Number of pages | 3 |
Journal | Structure |
Volume | 30 |
Issue number | 3 |
DOIs |
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State | Published - Mar 3 2022 |
Bibliographical note
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