DNA ligase and PCNA: Double-ring down to seal a break in DNA

Research output: Contribution to journalComment/debatepeer-review


In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.

Original languageEnglish (US)
Pages (from-to)324-326
Number of pages3
Issue number3
StatePublished - Mar 3 2022

Bibliographical note

Funding Information:
The author thanks Nicholas Moeller for helpful comments. H.A. is supported by NIGMS R35-GM118047 .

Publisher Copyright:
© 2022 Elsevier Ltd

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Comment


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