Abstract
DNA damage is the critical step linking carcinogen exposure from tobacco products to cancer-causing mutations in important growth control genes. This chapter provides an overview of carcinogens in tobacco products and their conversion to metabolites that react readily with DNA bases producing addition products known as DNA adducts found in smokers’ DNA. DNA adducts can cause errors during DNA replication leading to permanent changes in DNA sequence. When such mutations occur in critical regions of oncogenes such as KRAS and tumor suppressor genes such as p53, the result can be loss of normal growth control mechanisms and cancer development. This chapter presents evidence for this important biochemical pathway.
| Original language | English (US) |
|---|---|
| Title of host publication | Carcinogens, DNA Damage and Cancer Risk |
| Subtitle of host publication | Mechanisms of Chemical Carcinogenesis |
| Publisher | World Scientific Publishing Co. Ltd. |
| Pages | 69-86 |
| Number of pages | 18 |
| ISBN (Electronic) | 9789813237209 |
| ISBN (Print) | 9789813237193 |
| DOIs | |
| State | Published - Jan 1 2018 |
Bibliographical note
Publisher Copyright:© 2019 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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