DNA Damage by Tobacco Carcinogens

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

DNA damage is the critical step linking carcinogen exposure from tobacco products to cancer-causing mutations in important growth control genes. This chapter provides an overview of carcinogens in tobacco products and their conversion to metabolites that react readily with DNA bases producing addition products known as DNA adducts found in smokers’ DNA. DNA adducts can cause errors during DNA replication leading to permanent changes in DNA sequence. When such mutations occur in critical regions of oncogenes such as KRAS and tumor suppressor genes such as p53, the result can be loss of normal growth control mechanisms and cancer development. This chapter presents evidence for this important biochemical pathway.

Original languageEnglish (US)
Title of host publicationCarcinogens, DNA Damage and Cancer Risk
Subtitle of host publicationMechanisms of Chemical Carcinogenesis
PublisherWorld Scientific Publishing Co. Ltd.
Pages69-86
Number of pages18
ISBN (Electronic)9789813237209
ISBN (Print)9789813237193
DOIs
StatePublished - Jan 1 2018

Bibliographical note

Publisher Copyright:
© 2019 by World Scientific Publishing Co. Pte. Ltd. All rights reserved.

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