DNA confinement drives uncoating of the HIV Virus

I. Rouzina, R. Bruinsma

Research output: Contribution to journalArticle

3 Scopus citations


The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model for the uncoating of the HIV virus where the capsid uncoating process is driven by the confinement force exerted on the capsid wall porduced to the double-stranded DNA generated by reverse transcriptase.

Original languageEnglish (US)
Pages (from-to)1745-1754
Number of pages10
JournalEuropean Physical Journal: Special Topics
Issue number9
StatePublished - Sep 1 2014

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