The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model for the uncoating of the HIV virus where the capsid uncoating process is driven by the confinement force exerted on the capsid wall porduced to the double-stranded DNA generated by reverse transcriptase.
Bibliographical noteFunding Information:
IR acknowledges support from NIH Grant GM065056 and Professors Karin Musier-Forsyth, Alan Rein and Judith Levin for support and discussions. RFB acknowledges support by the Institute of Advanced Studies of the TUM and by the NSF under DMR Grant 1006128. We thank A. Grosberg for helpful discussion.