DNA and RNA in anhydrous media: Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent

Irena Mamajanov; Aaron E. Engelhart; Heather D. Bean; Nicholas V. Hud

doi:10.1002/anie.201001561

DNA and RNA in anhydrous media: Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent

Irena Mamajanov, Aaron E. Engelhart, Heather D. Bean, Nicholas V. Hud

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Article › peer-review

197 Scopus citations

Abstract

Hold the water! Deep-eutectic solvents (DESs) are nonvolatile media suitable for a wide range of chemical reactions. The discovery that nucleic acids can form duplex, triplex, and G quadruplex structures (which in some cases differ from those adopted in aqueous media) in a water-free DES (see picture) opens the enticing possibility that catalytic nucleic acids and enzyme-nucleic acid complexes could also be used in these solvents.

Original language	English (US)
Pages (from-to)	6310-6314
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	36
DOIs	https://doi.org/10.1002/anie.201001561
State	Published - Aug 23 2010

Keywords

DNA structures
Ionic liquids
Nucleic acids
Solvent effects
Sustainable chemistry

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10.1002/anie.201001561

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AU - Hud, Nicholas V.

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KW - Solvent effects

KW - Sustainable chemistry

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DNA and RNA in anhydrous media: Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent

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