TY - JOUR
T1 - Diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems
AU - Courville, Elizabeth L.
AU - Sohani, Aliyah R.
AU - Hasserjian, Robert P.
AU - Zukerberg, Lawrence R.
AU - Harris, Nancy L.
AU - Ferry, Judith A.
N1 - Publisher Copyright:
© American Society for Clinical Pathology.
PY - 2014/12
Y1 - 2014/12
N2 - Objectives: Human herpesvirus 8 (HHV8)-associated lymphomas are uncommon, mainly affect men infected with the human immunodeficiency virus (HIV), and usually have a poor prognosis. We sought to characterize the HHV8+ lymphomas seen at our institution since the mid-1990s. Methods: We identified 15 patients with HHV8-associated lymphomas and evaluated their clinical and pathologic features. Results: Diagnoses included primary effusion lymphoma (PEL) (n = 2), extracavitary PEL (n = 8), intravascular large B-cell lymphoma (n = 1), HHV8+ plasmablastic microlymphoma (n = 3), and germinotropic lymphoproliferative disorder (GLD) (n = 1). The case of GLD progressed to a high-grade HHV8+ Epstein-Barr virus-positive lymphoma, an evolution that has not been previously reported. Four patients were HIV- (three from an HHV8-endemic area). Potentially misleading pathologic features in our series of extracavitary PEL included classic Hodgkin lymphoma-like features, lymph node sinus involvement, and T-cell antigen expression. Conclusions: HHV8-associated lymphomas can be clinically and pathologically heterogeneous, with features that may lead to misdiagnosis as other types of lymphoma.
AB - Objectives: Human herpesvirus 8 (HHV8)-associated lymphomas are uncommon, mainly affect men infected with the human immunodeficiency virus (HIV), and usually have a poor prognosis. We sought to characterize the HHV8+ lymphomas seen at our institution since the mid-1990s. Methods: We identified 15 patients with HHV8-associated lymphomas and evaluated their clinical and pathologic features. Results: Diagnoses included primary effusion lymphoma (PEL) (n = 2), extracavitary PEL (n = 8), intravascular large B-cell lymphoma (n = 1), HHV8+ plasmablastic microlymphoma (n = 3), and germinotropic lymphoproliferative disorder (GLD) (n = 1). The case of GLD progressed to a high-grade HHV8+ Epstein-Barr virus-positive lymphoma, an evolution that has not been previously reported. Four patients were HIV- (three from an HHV8-endemic area). Potentially misleading pathologic features in our series of extracavitary PEL included classic Hodgkin lymphoma-like features, lymph node sinus involvement, and T-cell antigen expression. Conclusions: HHV8-associated lymphomas can be clinically and pathologically heterogeneous, with features that may lead to misdiagnosis as other types of lymphoma.
KW - Extracavitary primary effusion lymphoma
KW - Germinotropic lymphoproliferative disorder
KW - HHV8 lymphoma
KW - Human herpesvirus 8
KW - Multicentric castleman disease
KW - Plasmablastic microlymphoma
KW - Primary effusion lymphoma
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U2 - 10.1309/AJCPULI3W6WUGGPY
DO - 10.1309/AJCPULI3W6WUGGPY
M3 - Article
C2 - 25389336
AN - SCOPUS:84922324361
SN - 0002-9173
VL - 142
SP - 816
EP - 829
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 6
ER -