Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross

Matthew D. Martin, Ramakrishna Sompallae, Christina S. Winborn, John T. Harty, Vladimir P. Badovinac

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Enhanced host protection against re-infection requires generation of memory T cells of sufficient quantity and functional quality. Unlike well-studied inbred mice, T cell responses of diverse size and quality are generated following infection of humans and outbred mice. Thus, additional models are needed that accurately reflect variation in immune outcomes in genetically diverse populations and to uncover underlying genetic causes. The Collaborative Cross (CC), a large recombinant inbred panel of mice, is an ideal model in this pursuit for the high degree of genetic variation present, because it allows for assessment of genetic factors underlying unique phenotypes. Here, we advance the utility of the CC as a tool to analyze the immune response to viral infection. We describe variability in resting immune cell composition and adaptive immune responses generated among CC strains following systemic virus infection and reveal quantitative trait loci responsible for generation of CD62L+ memory CD8 T cells.

Original languageEnglish (US)
Article number107508
JournalCell reports
Volume31
Issue number2
DOIs
StatePublished - Apr 14 2020

Bibliographical note

Funding Information:
Funding for this study was provided from NIH grants AI42767 , AI85515 , and AI100527 (J.T.H.); AI114543 (J.T.H. and V.P.B.); and AI147064 , GM113961 , and GM134880 (V.P.B.). We wish to thank Dr. Anne Kwitek for initial help with QTL analysis and Ginger Shaw for help with procurement of Collaborative Cross mice used in this study.

Publisher Copyright:
© 2020 The Author(s)

Keywords

  • CD8 T cells
  • QTL mapping
  • central memory
  • collaborative cross
  • immunological memory
  • mouse models

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