Martin et al. advance the use of the Collaborative Cross (CC) for studying adaptive immune responses. They demonstrate that the CC better models variation in T cell responses seen in outbred mice and humans and that it can uncover genes linked to generation of qualitatively distinct memory cells following infection.
Bibliographical noteFunding Information:
Funding for this study was provided from NIH grants AI42767 , AI85515 , and AI100527 (J.T.H.); AI114543 (J.T.H. and V.P.B.); and AI147064 , GM113961 , and GM134880 (V.P.B.). We wish to thank Dr. Anne Kwitek for initial help with QTL analysis and Ginger Shaw for help with procurement of Collaborative Cross mice used in this study.
- CD8 T cells
- QTL mapping
- central memory
- collaborative cross
- immunological memory
- mouse models