Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats

Kerry C. Michael, Robert H. Bonneau, Rebecca A. Bourne, La Dara Godbolt, Michael J. Caruso, Christine Hohmann, Sonia A. Cavigelli

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    2 Scopus citations

    Abstract

    Stable behavioral traits (temperament, personality) often predict health outcomes. Temperament-specific differences in immune function could explain temperament-specific health outcomes, however, we have limited information on whether immune function varies by personality. In the present study, we examined the relationship between a basic behavioral trait (behavioral-inhibition vs. non-inhibition) and two immune responses (innate inflammation and delayed-type hypersensitivity, DTH) in a rodent model. In humans, behavioral inhibition (fearful temperament) is associated with altered stress physiology and allergies. In laboratory rats, the trait is associated with elevated glucocorticoid production. We hypothesized that behavioral inhibition is associated with glucocorticoid resistance and dampened T-helper 1 cell responses often associated with chronic stress and allergies. Further, this immune profile would predict poorly-regulated innate inflammation and dampened DTH. In male Sprague-Dawley rats, we quantified consistent behavioral phenotypes by measuring latency to contact two kinds of novelty (object vs. social), then measured lipopolysaccharide(LPS)-induced innate inflammation or keyhole limpet hemocyanin(KLH)-induced DTH. Behaviorally-inhibited rats had heightened glucocorticoid and interleukin-6 responses to a low/moderate dose of LPS and reduced DTH swelling to KLH re-exposure compared to non-inhibited rats. These results suggest that behavioral inhibition is associated with a glucocorticoid resistant state with poorly regulated innate inflammation and dampened cell-mediated immune responses. This immune profile may be associated with exaggerated T-helper 2 responses, which could set the stage for an allergic/asthmatic/atopic predisposition in inhibited individuals. Human and animal models of temperament-specific immune responses represent an area for further exploration of mechanisms involved in individual differences in health.

    Original languageEnglish (US)
    Article number112693
    JournalPhysiology and Behavior
    Volume213
    DOIs
    StatePublished - Jan 1 2020

    Bibliographical note

    Funding Information:
    We would like to acknowledge the many students that assisted with this project, in particular Wael Bahar, Nicole Chirichella, Brian Coleman, Mario DeNicola, Olivia Francois, Alisa Inthavongsa, Sammy Leathers, and Christina Ragan. Funding was provided by the National Institutes of Health ( R03MH071406 , R25GM058904 ), and The Pennsylvania State University (Pennsylvania State University Children, Youth and Families Consortium, and Pennsylvania State Institute for Neuroscience). We would like to dedicate this paper to Robert H. Bonneau; without his expert advice and guidance, this study was not possible. Rob was instrumental in the planning of this study and he provided unwavering support to SAC and KCM and to many other researchers both within and outside his laboratory. Rob was the ideal colleague – full of ideas and energy, supportive, and with high expectations. He is greatly missed.

    Funding Information:
    We would like to acknowledge the many students that assisted with this project, in particular Wael Bahar, Nicole Chirichella, Brian Coleman, Mario DeNicola, Olivia Francois, Alisa Inthavongsa, Sammy Leathers, and Christina Ragan. Funding was provided by the National Institutes of Health (R03MH071406, R25GM058904), and The Pennsylvania State University (Pennsylvania State University Children, Youth and Families Consortium, and Pennsylvania State Institute for Neuroscience). We would like to dedicate this paper to Robert H. Bonneau; without his expert advice and guidance, this study was not possible. Rob was instrumental in the planning of this study and he provided unwavering support to SAC and KCM and to many other researchers both within and outside his laboratory. Rob was the ideal colleague ? full of ideas and energy, supportive, and with high expectations. He is greatly missed.

    Keywords

    • Delayed type hypersensitivity
    • Individual differences
    • Inflammation
    • Innate immune response
    • Personality
    • Temperament

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