Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats

Kerry C. Michael, Robert H. Bonneau, Rebecca A. Bourne, La Dara Godbolt, Michael J. Caruso, Christine Hohmann, Sonia A. Cavigelli

    Research output: Contribution to journalArticle

    Abstract

    Stable behavioral traits (temperament, personality) often predict health outcomes. Temperament-specific differences in immune function could explain temperament-specific health outcomes, however, we have limited information on whether immune function varies by personality. In the present study, we examined the relationship between a basic behavioral trait (behavioral-inhibition vs. non-inhibition) and two immune responses (innate inflammation and delayed-type hypersensitivity, DTH) in a rodent model. In humans, behavioral inhibition (fearful temperament) is associated with altered stress physiology and allergies. In laboratory rats, the trait is associated with elevated glucocorticoid production. We hypothesized that behavioral inhibition is associated with glucocorticoid resistance and dampened T-helper 1 cell responses often associated with chronic stress and allergies. Further, this immune profile would predict poorly-regulated innate inflammation and dampened DTH. In male Sprague-Dawley rats, we quantified consistent behavioral phenotypes by measuring latency to contact two kinds of novelty (object vs. social), then measured lipopolysaccharide(LPS)-induced innate inflammation or keyhole limpet hemocyanin(KLH)-induced DTH. Behaviorally-inhibited rats had heightened glucocorticoid and interleukin-6 responses to a low/moderate dose of LPS and reduced DTH swelling to KLH re-exposure compared to non-inhibited rats. These results suggest that behavioral inhibition is associated with a glucocorticoid resistant state with poorly regulated innate inflammation and dampened cell-mediated immune responses. This immune profile may be associated with exaggerated T-helper 2 responses, which could set the stage for an allergic/asthmatic/atopic predisposition in inhibited individuals. Human and animal models of temperament-specific immune responses represent an area for further exploration of mechanisms involved in individual differences in health.

    Original languageEnglish (US)
    Article number112693
    JournalPhysiology and Behavior
    Volume213
    DOIs
    StatePublished - Jan 1 2020

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    Temperament
    Delayed Hypersensitivity
    Glucocorticoids
    Inflammation
    Lipopolysaccharides
    Personality
    Health
    Hypersensitivity
    Th1 Cells
    Innate Immunity
    Individuality
    Sprague Dawley Rats
    Rodentia
    Interleukin-6
    Animal Models
    Phenotype
    Inhibition (Psychology)

    Keywords

    • Delayed type hypersensitivity
    • Individual differences
    • Inflammation
    • Innate immune response
    • Personality
    • Temperament

    PubMed: MeSH publication types

    • Journal Article

    Cite this

    Michael, K. C., Bonneau, R. H., Bourne, R. A., Godbolt, L. D., Caruso, M. J., Hohmann, C., & Cavigelli, S. A. (2020). Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats. Physiology and Behavior, 213, [112693]. https://doi.org/10.1016/j.physbeh.2019.112693

    Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats. / Michael, Kerry C.; Bonneau, Robert H.; Bourne, Rebecca A.; Godbolt, La Dara; Caruso, Michael J.; Hohmann, Christine; Cavigelli, Sonia A.

    In: Physiology and Behavior, Vol. 213, 112693, 01.01.2020.

    Research output: Contribution to journalArticle

    Michael, KC, Bonneau, RH, Bourne, RA, Godbolt, LD, Caruso, MJ, Hohmann, C & Cavigelli, SA 2020, 'Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats', Physiology and Behavior, vol. 213, 112693. https://doi.org/10.1016/j.physbeh.2019.112693
    Michael KC, Bonneau RH, Bourne RA, Godbolt LD, Caruso MJ, Hohmann C et al. Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats. Physiology and Behavior. 2020 Jan 1;213. 112693. https://doi.org/10.1016/j.physbeh.2019.112693
    Michael, Kerry C. ; Bonneau, Robert H. ; Bourne, Rebecca A. ; Godbolt, La Dara ; Caruso, Michael J. ; Hohmann, Christine ; Cavigelli, Sonia A. / Divergent immune responses in behaviorally-inhibited vs. non-inhibited male rats. In: Physiology and Behavior. 2020 ; Vol. 213.
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