Divergent accumulation patterns of SNVs and INDELs reveal negative selection in noncancerous cells

Keyphrases

• Indel 100%
• Non-cancer 100%
• Negative Selection 100%
• Accumulation Pattern 100%
• Fibroblasts 66%
• Somatic mutation 66%
• MSH2 66%
• Mutation Accumulation 66%
• Clonal Amplification 66%
• Cell Culture 33%
• Aging 33%
• Growth Rate 33%
• Age-related 33%
• Specific Genes 33%
• Adverse Effects 33%
• Population Change 33%
• Human Tissue 33%
• Cell Behavior 33%
• Positive Selection 33%
• Single nucleotide Variant 33%
• Causal Role 33%
• Mismatch Repair 33%
• Functional Decline 33%
• Clonal Expansion 33%
• Plateaued 33%
• Cell Strain 33%
• Random mutation 33%
• DNA Mismatch Repair 33%
• Single-cell Whole-genome Sequencing 33%
• Strain-specific 33%

Biochemistry, Genetics and Molecular Biology

• Somatic Mutation 100%
• Mutation Accumulation 100%
• Fibroblast 100%
• Single-Nucleotide Polymorphism 50%
• Indel 50%
• Whole Genome Sequencing 50%
• Cell Culture 50%
• Cell Function 50%
• DNA Mismatch Repair 50%
• Population Dynamics 50%