Disturbance of pulmonary prostaglandin metabolism in fetuses of alloxan-diabetic rabbits

Michael Y Tsai; Luke E. Schallinger; Mark W. Josephson; David M. Brown

doi:10.1016/0005-2760(82)90358-7

Disturbance of pulmonary prostaglandin metabolism in fetuses of alloxan-diabetic rabbits

Michael Y Tsai
, Luke E. Schallinger
, Mark W. Josephson
, David M. Brown

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

[¹⁴C]Arachidonic acid conversion in lung homogenates of 28-day fetuses from control and alloxan-diabetic rabbits was studied. The major metabolites were 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid and prostaglandin E₂. Small amounts of 6-ketoprostaglandin F_1α prostaglandin F_2α, and thromboxane B₂ were also observed. Lung homogenates from fetuses of alloxan-diabetic rabbits convert significantly less [¹⁴C]arachidonic acid to prostaglandin E₂, whereas all other metabolites were present in similar quantities compared to fetuses of non-diabetic rabbits. These studies suggest that the decreased arachidonic acid conversion to prostaglandin E₂ could be partially responsible for the functional delay of lung maturation in offspring of alloxan-diabetic rabbits.

Original language	English (US)
Pages (from-to)	395-399
Number of pages	5
Journal	Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume	712
Issue number	2
DOIs	https://doi.org/10.1016/0005-2760(82)90358-7
State	Published - Aug 18 1982

Bibliographical note

Funding Information:
The authors wish to thank Dr. Patrick Wong for his advice and help, and Brad Syverson, Barbara Jensen and Penny Bagne for their expert technical assistance. This study was supported in part by grants from the Juvenile Diabetes Foundation (79R139), the Minnesota Medical Foundation (DRF-3-78), the American Diabetes Association, Minnesota Affiliate, the Graduate School of the University of Minnesota (M.Y.T.), and NIH grant AM-16797 (D.M.B.).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

(Fetal rabbit lung)
Diabetes
Prostaglandin metabolism
Respiratory distress

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title = "Disturbance of pulmonary prostaglandin metabolism in fetuses of alloxan-diabetic rabbits",

abstract = "[14C]Arachidonic acid conversion in lung homogenates of 28-day fetuses from control and alloxan-diabetic rabbits was studied. The major metabolites were 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid and prostaglandin E2. Small amounts of 6-ketoprostaglandin F1α prostaglandin F2α, and thromboxane B2 were also observed. Lung homogenates from fetuses of alloxan-diabetic rabbits convert significantly less [14C]arachidonic acid to prostaglandin E2, whereas all other metabolites were present in similar quantities compared to fetuses of non-diabetic rabbits. These studies suggest that the decreased arachidonic acid conversion to prostaglandin E2 could be partially responsible for the functional delay of lung maturation in offspring of alloxan-diabetic rabbits.",

keywords = "(Fetal rabbit lung), Diabetes, Prostaglandin metabolism, Respiratory distress",

author = "Tsai, \{Michael Y\} and Schallinger, \{Luke E.\} and Josephson, \{Mark W.\} and Brown, \{David M.\}",

note = "Funding Information: The authors wish to thank Dr. Patrick Wong for his advice and help, and Brad Syverson, Barbara Jensen and Penny Bagne for their expert technical assistance. This study was supported in part by grants from the Juvenile Diabetes Foundation (79R139), the Minnesota Medical Foundation (DRF-3-78), the American Diabetes Association, Minnesota Affiliate, the Graduate School of the University of Minnesota (M.Y.T.), and NIH grant AM-16797 (D.M.B.).",

year = "1982",

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doi = "10.1016/0005-2760(82)90358-7",

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AU - Tsai, Michael Y

AU - Schallinger, Luke E.

AU - Josephson, Mark W.

AU - Brown, David M.

N1 - Funding Information: The authors wish to thank Dr. Patrick Wong for his advice and help, and Brad Syverson, Barbara Jensen and Penny Bagne for their expert technical assistance. This study was supported in part by grants from the Juvenile Diabetes Foundation (79R139), the Minnesota Medical Foundation (DRF-3-78), the American Diabetes Association, Minnesota Affiliate, the Graduate School of the University of Minnesota (M.Y.T.), and NIH grant AM-16797 (D.M.B.).

PY - 1982/8/18

Y1 - 1982/8/18

N2 - [14C]Arachidonic acid conversion in lung homogenates of 28-day fetuses from control and alloxan-diabetic rabbits was studied. The major metabolites were 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid and prostaglandin E2. Small amounts of 6-ketoprostaglandin F1α prostaglandin F2α, and thromboxane B2 were also observed. Lung homogenates from fetuses of alloxan-diabetic rabbits convert significantly less [14C]arachidonic acid to prostaglandin E2, whereas all other metabolites were present in similar quantities compared to fetuses of non-diabetic rabbits. These studies suggest that the decreased arachidonic acid conversion to prostaglandin E2 could be partially responsible for the functional delay of lung maturation in offspring of alloxan-diabetic rabbits.

AB - [14C]Arachidonic acid conversion in lung homogenates of 28-day fetuses from control and alloxan-diabetic rabbits was studied. The major metabolites were 12-l-hydroxy-5,8,10,14-eicosatetraenoic acid and prostaglandin E2. Small amounts of 6-ketoprostaglandin F1α prostaglandin F2α, and thromboxane B2 were also observed. Lung homogenates from fetuses of alloxan-diabetic rabbits convert significantly less [14C]arachidonic acid to prostaglandin E2, whereas all other metabolites were present in similar quantities compared to fetuses of non-diabetic rabbits. These studies suggest that the decreased arachidonic acid conversion to prostaglandin E2 could be partially responsible for the functional delay of lung maturation in offspring of alloxan-diabetic rabbits.

KW - (Fetal rabbit lung)

KW - Diabetes

KW - Prostaglandin metabolism

KW - Respiratory distress

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Disturbance of pulmonary prostaglandin metabolism in fetuses of alloxan-diabetic rabbits

Abstract

Bibliographical note

UN SDGs

Keywords

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