Distribution of peripheral lymphocytes in Alzheimer patients and controls

Maurice W. Dysken, Marcia D. Minichiello, James L. Hill, Stacy Skare, John T. Little, Susan E. Molchan, Trey Sunderland

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Deficient immunoregulation has been postulated to play a role in the pathogenesis of Alzheimer's dementia. Recently, lymphopenia was reported to be more prevalent in Alzheimer patients than in control subjects. In addition, a decreasing number of total lymphocytes was found to be significantly correlated with increasing severity of dementia. In an attempt to replicate these findings, we studied 55 Alzheimer patients and 41 healthy controls of comparable age and gender, but found no significant difference in the distribution of total lymphocytes between these groups. Furthermore, total lymphocytes were not significantly correlated with dementia severity. Our findings, therefore, do not lend further support to an immune hypothesis for Alzheimer's dementia.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalJournal of Psychiatric Research
Volume26
Issue number3
DOIs
StatePublished - Jul 1992

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