Distribution of nicotinic binding sites with respect to CRF and neurophysin immunoreactive perikarya within the rat hypothalamus

B. M. Sharp; S. Nicol; S. Cummings; Virginia S Seybold

doi:10.1016/0006-8993(87)90945-0

Distribution of nicotinic binding sites with respect to CRF and neurophysin immunoreactive perikarya within the rat hypothalamus

B. M. Sharp
, S. Nicol
, S. Cummings
, Virginia S Seybold

Neuroscience

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

These studies determined the differential autoradiographic distribution of [¹²⁵I]α-bungarotoxin versus [³H]nicotine relative to the histochemically defined perikarya for neurophysin and corticotropin releasing factor (CRF). Specific [³H]nicotine binding sites occured in relatively greater density within the neuropil surrounding PVN and SON compared to within the nuclei. In contrast, the highest density of [¹²⁵I]α-BTX sites codistributed with neurophysin immunoreactive perikarya within these nuclei.

Original language	English (US)
Pages (from-to)	361-366
Number of pages	6
Journal	Brain Research
Volume	422
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90945-0
State	Published - Oct 6 1987

Keywords

Corticotropin releasing factor (CRF)
Hypothalamus
Neurophysin
Nicotic site

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10.1016/0006-8993(87)90945-0

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title = "Distribution of nicotinic binding sites with respect to CRF and neurophysin immunoreactive perikarya within the rat hypothalamus",

abstract = "These studies determined the differential autoradiographic distribution of [125I]α-bungarotoxin versus [3H]nicotine relative to the histochemically defined perikarya for neurophysin and corticotropin releasing factor (CRF). Specific [3H]nicotine binding sites occured in relatively greater density within the neuropil surrounding PVN and SON compared to within the nuclei. In contrast, the highest density of [125I]α-BTX sites codistributed with neurophysin immunoreactive perikarya within these nuclei.",

keywords = "Corticotropin releasing factor (CRF), Hypothalamus, Neurophysin, Nicotic site",

author = "Sharp, \{B. M.\} and S. Nicol and S. Cummings and Seybold, \{Virginia S\}",

year = "1987",

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doi = "10.1016/0006-8993(87)90945-0",

language = "English (US)",

volume = "422",

pages = "361--366",

journal = "Brain Research",

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T1 - Distribution of nicotinic binding sites with respect to CRF and neurophysin immunoreactive perikarya within the rat hypothalamus

AU - Sharp, B. M.

AU - Nicol, S.

AU - Cummings, S.

AU - Seybold, Virginia S

PY - 1987/10/6

Y1 - 1987/10/6

N2 - These studies determined the differential autoradiographic distribution of [125I]α-bungarotoxin versus [3H]nicotine relative to the histochemically defined perikarya for neurophysin and corticotropin releasing factor (CRF). Specific [3H]nicotine binding sites occured in relatively greater density within the neuropil surrounding PVN and SON compared to within the nuclei. In contrast, the highest density of [125I]α-BTX sites codistributed with neurophysin immunoreactive perikarya within these nuclei.

AB - These studies determined the differential autoradiographic distribution of [125I]α-bungarotoxin versus [3H]nicotine relative to the histochemically defined perikarya for neurophysin and corticotropin releasing factor (CRF). Specific [3H]nicotine binding sites occured in relatively greater density within the neuropil surrounding PVN and SON compared to within the nuclei. In contrast, the highest density of [125I]α-BTX sites codistributed with neurophysin immunoreactive perikarya within these nuclei.

KW - Corticotropin releasing factor (CRF)

KW - Hypothalamus

KW - Neurophysin

KW - Nicotic site

UR - https://www.scopus.com/pages/publications/0023578959

UR - https://www.scopus.com/pages/publications/0023578959#tab=citedBy

U2 - 10.1016/0006-8993(87)90945-0

DO - 10.1016/0006-8993(87)90945-0

M3 - Article

C2 - 3499957

AN - SCOPUS:0023578959

SN - 0006-8993

VL - 422

SP - 361

EP - 366

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Distribution of nicotinic binding sites with respect to CRF and neurophysin immunoreactive perikarya within the rat hypothalamus

Abstract

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