Distribution of nicotinic binding sites with respect to CRF and neurophysin immunoreactive perikarya within the rat hypothalamus

B. M. Sharp, S. Nicol, S. Cummings, Virginia S Seybold

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

These studies determined the differential autoradiographic distribution of [125I]α-bungarotoxin versus [3H]nicotine relative to the histochemically defined perikarya for neurophysin and corticotropin releasing factor (CRF). Specific [3H]nicotine binding sites occured in relatively greater density within the neuropil surrounding PVN and SON compared to within the nuclei. In contrast, the highest density of [125I]α-BTX sites codistributed with neurophysin immunoreactive perikarya within these nuclei.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalBrain Research
Volume422
Issue number2
DOIs
StatePublished - Oct 6 1987

Keywords

  • Corticotropin releasing factor (CRF)
  • Hypothalamus
  • Neurophysin
  • Nicotic site

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