Distribution of neurotransmitter binding sites in the cat median eminence

Virginia S Seybold, B. J. Wilcox

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Receptor autoradiography was used to determine the distribution binding sites for monoaminergic and cholinergic neurotransmitters in the cat median eminence. Resulsts showed that binding sites were differentially distributed in that [3H]-p-aminoclonidine (an alpha-2-adrenergic ligand) and [3H]pyrilamine (an H1-histaminergic ligand) binding were concentrated in the medial region of the external layer of the median eminence while [3H]lysergic acid diethylamide (a serotonergic ligand) and [3H] quinuclidinyl benzilate (a muscarinic cholinergic ligand) binding were concentrated within the lateral region of the external layer. These patterns are coincident with the differential distributions of hypophysiotropic hormones in the median eminence, suggesting that monoamines and acetylcholine may regulate the release of these hormones at the level of the median eminence.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalNeuroendocrinology
Volume46
Issue number1
DOIs
StatePublished - Jan 1 1987

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Median Eminence
Neurotransmitter Agents
Cats
Binding Sites
Cholinergic Agents
Ligands
Quinuclidinyl Benzilate
Pituitary Hormone-Releasing Hormones
Pyrilamine
Lysergic Acid Diethylamide
Autoradiography
Adrenergic Agents
Acetylcholine
Hormones

Cite this

Distribution of neurotransmitter binding sites in the cat median eminence. / Seybold, Virginia S; Wilcox, B. J.

In: Neuroendocrinology, Vol. 46, No. 1, 01.01.1987, p. 32-38.

Research output: Contribution to journalArticle

Seybold, Virginia S ; Wilcox, B. J. / Distribution of neurotransmitter binding sites in the cat median eminence. In: Neuroendocrinology. 1987 ; Vol. 46, No. 1. pp. 32-38.
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