Distribution of lipoproteins and apolipoproteins in young adults. The CARDIA study.

R. P. Donahue, D. R. Jacobs, S. Sidney, L. E. Wagenknecht, J. J. Albers, S. B. Hulley

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

While there are many studies of the distribution of coronary heart disease risk factors in children, adolescents, and middle-aged adults, little information is available on this topic in young adults. The Coronary Artery Risk Development in Young Adults Study (CARDIA) examined 4858 men and women who fasted 10 or more hours, were aged 18 to 30, and were representative of black and white residents of four U.S. communities. Compared with white men, black men had higher age-adjusted mean levels of high density lipoprotein cholesterol (HDL-C) (6.7 mg/dl, p<0.001) and apolipoprotein A-l (apo Al) (9.1 mg/dl, p<0.001) and lower concentrations of triglycerides (-19.7 mg/dl, p<0.001) and apolipoprotein B (apo B) (-3.3 mg/dl, p<0.001). Compared with white women, black women displayed higher concentrations of low density lipoprotein cholesterol (LDL-C) (5.7 mg/dl, p<0.001), apo A-l (2.6 mg/dl, p<0.001), and apo B (3.0 mg/dl, p<0.001), but lower triglycerides (-5.8 mg/dl, p=0.001). Gender differences were more pronounced among whites: white men displayed lower mean levels of HDL-C and apo A-l (-9.2 and -7.3 mg/dl, p<0.001) and higher concentrations of LDL-C, triglycerides, and apo B (5.2, 20.3, and 5.3 mg/dl, p<0.001) than white women. Attained level of education was significantly associated with a favorable lipoprotein/apolipoprotein profile, particularly among white women. These data indicate substantial variation in the distribution of lipoproteins and apolipoproteins in young audlts, which may be important determinants of future coronary disease risk.

Original languageEnglish (US)
Pages (from-to)656-664
Number of pages9
JournalArteriosclerosis
Volume9
Issue number5
DOIs
StatePublished - 1989

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