Distribution of histaminergic, muscarinic and serotonergic binding sites in cat spinal cord with emphasis on the region surrounding the central canal

V. S. Seybold

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

[3H]Quinuclidinyl benzilate (QNB), [3H]lysergic acid diethylamide (LSD) and [3H]pyrilamine were used with radiohistochemistry to determine the distribution of muscarinic, serotonergic and histaminergic binding sites, respectively, in cat spinal cord. Each ligand displayed a unique pattern of binding sites in the superficial laminae of the dorsal horn [3H]Pyrilamine binding sites were localized most superficially, while [3H]LSD binding sites were densest in the region of the laminae II/III border. The distribution of [3H]QNB binding sites partially overlapped those of LSD and pyrilamine. In the region surrounding the central canal, pyrilamine binding sites were concentrated within a zone 100 μm lateral to the canal while [3H]QNB and [3H]LSD binding sites were localized outside of this zone. The distribution of binding sites in the region surrounding the central canal may provide an important neurochemical correlate for lamina X in the cat as defined by Rexed.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalBrain Research
Volume342
Issue number2
DOIs
StatePublished - Sep 9 1985

Keywords

  • cat
  • dorsal horn
  • histaminergic receptor
  • lamina X
  • muscarinic receptor
  • serotonergic receptor
  • spinal cord

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