Distribution coefficient of rifabutin in liposome/water system as measured by different methods

Vitaly V. Vostrikov; Alla A. Selishcheva; Galina M. Sorokoumova; Yulia N. Shakina; Vitaly I. Shvets; Oleg Yu Savel'ev; Vladimir I. Polshakov

doi:10.1016/j.ejpb.2007.05.014

Distribution coefficient of rifabutin in liposome/water system as measured by different methods

Vitaly V. Vostrikov
, Alla A. Selishcheva
, Galina M. Sorokoumova
, Yulia N. Shakina
, Vitaly I. Shvets
, Oleg Yu Savel'ev
, Vladimir I. Polshakov

Biochemistry, Molecular Biology, and Biophysics (TMED)

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Distribution coefficient (D) of rifabutin in liposome/water system was measured by phase separation and fluorescence probe quenching techniques. D values were identical suggesting that rifabutin is fully immersed into lipid bilayer. Structural studies of phospholipid bilayer employing ³¹P NMR spectroscopy demonstrated that introduction of rifabutin does not alter the bilayer structure. A scheme of the rifabutin position in lipid bilayer based on the calculated size of rifabutin molecule is proposed.

Original language	English (US)
Pages (from-to)	400-405
Number of pages	6
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/j.ejpb.2007.05.014
State	Published - Feb 2008

Keywords

Distribution coefficient
Fluorescence
Liposomes
P NMR
Rifabutin

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10.1016/j.ejpb.2007.05.014

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title = "Distribution coefficient of rifabutin in liposome/water system as measured by different methods",

abstract = "Distribution coefficient (D) of rifabutin in liposome/water system was measured by phase separation and fluorescence probe quenching techniques. D values were identical suggesting that rifabutin is fully immersed into lipid bilayer. Structural studies of phospholipid bilayer employing 31P NMR spectroscopy demonstrated that introduction of rifabutin does not alter the bilayer structure. A scheme of the rifabutin position in lipid bilayer based on the calculated size of rifabutin molecule is proposed.",

keywords = "Distribution coefficient, Fluorescence, Liposomes, P NMR, Rifabutin",

author = "Vostrikov, \{Vitaly V.\} and Selishcheva, \{Alla A.\} and Sorokoumova, \{Galina M.\} and Shakina, \{Yulia N.\} and Shvets, \{Vitaly I.\} and Savel'ev, \{Oleg Yu\} and Polshakov, \{Vladimir I.\}",

year = "2008",

month = feb,

doi = "10.1016/j.ejpb.2007.05.014",

language = "English (US)",

volume = "68",

pages = "400--405",

journal = "European Journal of Pharmaceutics and Biopharmaceutics",

issn = "0939-6411",

publisher = "Elsevier B.V.",

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T1 - Distribution coefficient of rifabutin in liposome/water system as measured by different methods

AU - Vostrikov, Vitaly V.

AU - Selishcheva, Alla A.

AU - Sorokoumova, Galina M.

AU - Shakina, Yulia N.

AU - Shvets, Vitaly I.

AU - Savel'ev, Oleg Yu

AU - Polshakov, Vladimir I.

PY - 2008/2

Y1 - 2008/2

N2 - Distribution coefficient (D) of rifabutin in liposome/water system was measured by phase separation and fluorescence probe quenching techniques. D values were identical suggesting that rifabutin is fully immersed into lipid bilayer. Structural studies of phospholipid bilayer employing 31P NMR spectroscopy demonstrated that introduction of rifabutin does not alter the bilayer structure. A scheme of the rifabutin position in lipid bilayer based on the calculated size of rifabutin molecule is proposed.

AB - Distribution coefficient (D) of rifabutin in liposome/water system was measured by phase separation and fluorescence probe quenching techniques. D values were identical suggesting that rifabutin is fully immersed into lipid bilayer. Structural studies of phospholipid bilayer employing 31P NMR spectroscopy demonstrated that introduction of rifabutin does not alter the bilayer structure. A scheme of the rifabutin position in lipid bilayer based on the calculated size of rifabutin molecule is proposed.

KW - Distribution coefficient

KW - Fluorescence

KW - Liposomes

KW - P NMR

KW - Rifabutin

UR - https://www.scopus.com/pages/publications/37849009597

UR - https://www.scopus.com/pages/publications/37849009597#tab=citedBy

U2 - 10.1016/j.ejpb.2007.05.014

DO - 10.1016/j.ejpb.2007.05.014

M3 - Article

C2 - 17614265

AN - SCOPUS:37849009597

SN - 0939-6411

VL - 68

SP - 400

EP - 405

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

IS - 2

ER -

Distribution coefficient of rifabutin in liposome/water system as measured by different methods

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