Distribution and metabolism of leukotriene C4 after cisternal injection in guinea pigs

S. K. Juhn; L. Orning; S. Hammarström; P. Hedqvist; J. Wersäll

doi:10.1016/0952-3278(89)90052-5

Distribution and metabolism of leukotriene C₄ after cisternal injection in guinea pigs

S. K. Juhn, L. Orning, S. Hammarström, P. Hedqvist, J. Wersäll

Otolaryngology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Following cisternal injection of [³H₈]LTC₄ into guinea pigs, leukotriene metabolites were identified in the brain, cerebellum, perilymph, blood, liver and kidneys. LTC₄ was metabolized into LTD₄ and LTE₄ in the cerebrospinal fluid and LTE₄ was transported into the blood for general circulation and uptake into the liver and kidneys. The excretion of LTE₄ from CNS to blood seemed to be the rate-limiting step in the elimination of leukotrienes from the body. Leukotrienes were also transported into the perilymph. The conversion of LTC₄ into LTD₄ and LTE₄ was lower in perilymph as compared to the cerebrospinal fluid, suggesting a rate limiting function of the cochlear aqueduct that can be defined as a cerebrospinal fluid-labyrinth barrier.

Original language	English (US)
Pages (from-to)	135-141
Number of pages	7
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/0952-3278(89)90052-5
State	Published - Jun 1989

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title = "Distribution and metabolism of leukotriene C4 after cisternal injection in guinea pigs",

abstract = "Following cisternal injection of [3H8]LTC4 into guinea pigs, leukotriene metabolites were identified in the brain, cerebellum, perilymph, blood, liver and kidneys. LTC4 was metabolized into LTD4 and LTE4 in the cerebrospinal fluid and LTE4 was transported into the blood for general circulation and uptake into the liver and kidneys. The excretion of LTE4 from CNS to blood seemed to be the rate-limiting step in the elimination of leukotrienes from the body. Leukotrienes were also transported into the perilymph. The conversion of LTC4 into LTD4 and LTE4 was lower in perilymph as compared to the cerebrospinal fluid, suggesting a rate limiting function of the cochlear aqueduct that can be defined as a cerebrospinal fluid-labyrinth barrier.",

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AU - Juhn, S. K.

AU - Orning, L.

AU - Hammarström, S.

AU - Hedqvist, P.

AU - Wersäll, J.

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N2 - Following cisternal injection of [3H8]LTC4 into guinea pigs, leukotriene metabolites were identified in the brain, cerebellum, perilymph, blood, liver and kidneys. LTC4 was metabolized into LTD4 and LTE4 in the cerebrospinal fluid and LTE4 was transported into the blood for general circulation and uptake into the liver and kidneys. The excretion of LTE4 from CNS to blood seemed to be the rate-limiting step in the elimination of leukotrienes from the body. Leukotrienes were also transported into the perilymph. The conversion of LTC4 into LTD4 and LTE4 was lower in perilymph as compared to the cerebrospinal fluid, suggesting a rate limiting function of the cochlear aqueduct that can be defined as a cerebrospinal fluid-labyrinth barrier.

AB - Following cisternal injection of [3H8]LTC4 into guinea pigs, leukotriene metabolites were identified in the brain, cerebellum, perilymph, blood, liver and kidneys. LTC4 was metabolized into LTD4 and LTE4 in the cerebrospinal fluid and LTE4 was transported into the blood for general circulation and uptake into the liver and kidneys. The excretion of LTE4 from CNS to blood seemed to be the rate-limiting step in the elimination of leukotrienes from the body. Leukotrienes were also transported into the perilymph. The conversion of LTC4 into LTD4 and LTE4 was lower in perilymph as compared to the cerebrospinal fluid, suggesting a rate limiting function of the cochlear aqueduct that can be defined as a cerebrospinal fluid-labyrinth barrier.

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