Distinct Translational Control in CD4+ T Cell Subsets

Eva Bjur, Ola Larsson, Ekaterina Yurchenko, Lei Zheng, Valentina Gandin, Ivan Topisirovic, Shui Li, Carston R Wagner, Nahum Sonenberg, Ciriaco A. Piccirillo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression studies have defined canonical signatures of T cell subsets. Changes in steady-state mRNA levels, however, often do not reflect those of corresponding proteins due to post-transcriptional mechanisms including mRNA translation. Here, we unveil a unique translational signature, contrasting CD4+Foxp3+ regulatory T (TFoxp3+) and CD4+Foxp3- non-regulatory T (TFoxp3-) cells, which imprints subset-specific protein expression. We further show that translation of eukaryotic translation initiation factor 4E (eIF4E) is induced during T cell activation and, in turn, regulates translation of cell cycle related mRNAs and proliferation in both TFoxp3- and TFoxp3+ cells. Unexpectedly, eIF4E also affects Foxp3 expression and thereby lineage identity. Thus, mRNA-specific translational control directs both common and distinct cellular processes in CD4+ T cell subsets.

Original languageEnglish (US)
Article numbere1003494
JournalPLoS genetics
Volume9
Issue number5
DOIs
StatePublished - May 1 2013

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T-Lymphocyte Subsets
translation (genetics)
T-lymphocytes
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factors
Messenger RNA
protein
homeostasis
genome
tolerance
Self Tolerance
Protein Biosynthesis
Regulatory T-Lymphocytes
Cell Cycle
Proteins
Homeostasis
Transcription Factors
Genome
cell cycle
T-Lymphocytes

Cite this

Bjur, E., Larsson, O., Yurchenko, E., Zheng, L., Gandin, V., Topisirovic, I., ... Piccirillo, C. A. (2013). Distinct Translational Control in CD4+ T Cell Subsets. PLoS genetics, 9(5), [e1003494]. https://doi.org/10.1371/journal.pgen.1003494

Distinct Translational Control in CD4+ T Cell Subsets. / Bjur, Eva; Larsson, Ola; Yurchenko, Ekaterina; Zheng, Lei; Gandin, Valentina; Topisirovic, Ivan; Li, Shui; Wagner, Carston R; Sonenberg, Nahum; Piccirillo, Ciriaco A.

In: PLoS genetics, Vol. 9, No. 5, e1003494, 01.05.2013.

Research output: Contribution to journalArticle

Bjur, E, Larsson, O, Yurchenko, E, Zheng, L, Gandin, V, Topisirovic, I, Li, S, Wagner, CR, Sonenberg, N & Piccirillo, CA 2013, 'Distinct Translational Control in CD4+ T Cell Subsets', PLoS genetics, vol. 9, no. 5, e1003494. https://doi.org/10.1371/journal.pgen.1003494
Bjur E, Larsson O, Yurchenko E, Zheng L, Gandin V, Topisirovic I et al. Distinct Translational Control in CD4+ T Cell Subsets. PLoS genetics. 2013 May 1;9(5). e1003494. https://doi.org/10.1371/journal.pgen.1003494
Bjur, Eva ; Larsson, Ola ; Yurchenko, Ekaterina ; Zheng, Lei ; Gandin, Valentina ; Topisirovic, Ivan ; Li, Shui ; Wagner, Carston R ; Sonenberg, Nahum ; Piccirillo, Ciriaco A. / Distinct Translational Control in CD4+ T Cell Subsets. In: PLoS genetics. 2013 ; Vol. 9, No. 5.
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