Distinct prefrontal activations in processing sequence at the sentence and script level: An fMRI study

Sophie Crozier, Angela Sirigu, Stéphane Lehéricy, Pierre François Van De Moortele, Bernard Pillon, Jordan Grafman, Yves Agid, Bruno Dubois, Denis Lebihan

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


Neuropsychological studies have shown that the prefrontal cortex is important in planning and monitoring everyday behaviour. In this study, using functional magnetic resonance imaging (fMRI), we investigated whether specific prefrontal regions are involved in processing a sequence of actions. Subjects were required to perform two different tasks: Script-event order and Sentence-word order. Script sequence and word sequence processing were found to activate partially overlapping areas which are known to be implicated in language processing. In addition, the Script-task activated a large area in the dorsolateral prefrontal cortex (Brodmann area 6 and 8, BA 6 and 8), in both the left and right hemispheres, as well as the left supplementary motor area and left angular gyrus (BA 39). Our results suggest that these prefrontal areas may be more specifically involved in the process of analysing sequential links in the action domain.

Original languageEnglish (US)
Pages (from-to)1469-1476
Number of pages8
Issue number13
StatePublished - Dec 1999

Bibliographical note

Funding Information:
This research was funded by GIS-CNRS to A.S. and by the Fondation pour la Recherche Médicale to S.C.


  • Action sequence
  • Frontal lobes
  • Neuropsychology
  • Planning
  • Temporal order


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